Evidence map›Paper›PMID 41201205›Full record

ArticleEuropean journal of neurology2025

Cognitive Reserve in Amyotrophic Lateral Sclerosis: A 2-[

Antonio Canosa, Stefano Callegaro, Umberto Manera, Rosario Vasta, Sara Cabras, Francesca Di Pede, Filippo De Mattei, Francesca Palumbo, Barbara Iazzolino, Anastasia Dei Giudici and 18 more

Abstract read
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In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Suicide in neurodegenerative diseases: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Antonio CanosaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Stefano CallegaroALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Umberto ManeraALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Rosario VastaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Sara CabrasALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0002-4988-2855
Francesca Di PedeALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Filippo De MatteiALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Francesca PalumboALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Barbara IazzolinoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Anastasia Dei GiudiciALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Enrico MatteoniALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Grazia ZoccoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Emilio MinervaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Alessandra MaccabeoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Giorgio PellegrinoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Daniela PascariuALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Maurizio GrassanoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Francesco CiresiALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Marcella TestaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Giulia PolverariPositron Emission Tomography Centre AFFIDEA-IRMET S.p.A., Turin, Italy.
Paolina SalamoneALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Giovanni De MarcoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Claudia PaolantonioALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Giulia MarcheseALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Cristina MogliaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Andrea CalvoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0002-5122-7243
Adriano ChiòALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0001-9579-5341
Marco PaganiInstitute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy.

Funding

A.S.D. Polisportiva U.I.C.I Torino OnlusFondation Thierry LatranHorizon 2020 Framework Programme 101137074Horizon 2020 Framework Programme GA101017598Ministero della Salute RF-2016-02362405Ministero dell'Università e della Ricerca PRIN 2017SNW5MBMinistry of Education, University and Research of ItalyMinistry of HealthSeventh Framework Programme 259867
6 · The paper itself

Abstract

backgroundCognitive reserve (CR) applies to ALS-related cognitive impairment and education is a CR proxy. The influence of sex on CR in ALS is unclear.

methodsWe compared brain 2-[

resultsM-ALS showed a relative hypometabolism compared to f-ALS in bilateral frontotemporal regions. In f-ALS brain metabolism positively correlated with education in the left fusiform gyrus, cerebellum and pons. The IRCA showed a positive correlation of the seed region with the cerebellum, pons, right fusiform gyrus and cuneus, and the left precuneus, and a negative correlation with the frontal lobes and caudate nuclei. In m-ALS brain metabolism negatively correlated with education in the left frontotemporal and insular cortices. The IRCA showed a positive correlation of the seed region with bilateral frontotemporal and cingulate cortices, and the right parietal cortex, and a negative correlation with bilateral cerebellum and motor cortex, and the left lingual gyrus.

conclusionsM-ALS showed relative frontotemporal hypometabolism compared to f-ALS, suggesting a male prevalence of CR. In m-ALS the negative correlation of education with left frontotemporal and insular metabolism supports the CR hypothesis. In f-ALS the positive correlation of cerebellar metabolism with education suggests compensatory mechanisms, also supported by the IRCA.

Indexed as

Amyotrophic Lateral SclerosisBrainCognitive ReserveSex CharacteristicsAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsFluorodeoxyglucose F18Radiopharmaceuticals2‐[18F]FDG‐PETamyotrophic lateral sclerosiscognitioncognitive reservesex

Identifiers

PMID41201205
PMCPMC12593548

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.