Evidence map›Paper›PMID 41201292›Full record

ArticleInvestigative ophthalmology & visual science2025

Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease.

Xingyu Zhu, Han Ye, Yiteng Lu, Qingye Zhang, Hong Zhang, Yuqing Wu, Yirou Zhang, Yawei Chai, Yuyu Cao, Jiaxu Hong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xingyu ZhuDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Han YeDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Yiteng LuDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Qingye ZhangDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Hong ZhangDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Yuqing WuDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Yirou ZhangDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Yawei ChaiDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Yuyu CaoDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Jiaxu HongDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.
Xujiao ZhouDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate the therapeutic effects of pasireotide (SOM230) on corneal nerve abnormalities in a mouse model of dry eye disease (DED) and to elucidate its potential mechanisms of action. Methods: Male C57BL/6J mice underwent lacrimal gland excision (LGE) to induce DED and were treated with SOM230 or PBS. Corneal epithelial integrity, pain-related behaviors, and corneal sensitivity were evaluated. RNA sequencing was performed to identify potential pathways modulated by SOM230. Flow cytometry and immunofluorescence quantified macrophage polarization states. Results: SOM230 treatment significantly improved corneal epithelial integrity, reduced pain behaviors, and restored corneal sensitivity compared to PBS. RNA sequencing revealed that SOM230 downregulated key inflammatory pathways, including TNF-α and NF-κB. Flow cytometry and immunofluorescence showed that SOM230 modulated macrophage polarization by decreasing pro-inflammatory M1 macrophages and enhancing anti-inflammatory M2 macrophages, contributing to reduced corneal inflammation and improved healing. Conclusions: SOM230 alleviates nerve abnormalities in DED by suppressing inflammatory pathways (TNF-α, NF-κB) and promoting a shift in macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype. These findings suggest that modulation of macrophage polarization is a crucial mechanism underlying the therapeutic effects of SOM230, highlighting its potential as a treatment strategy for nerve damage in DED.

Indexed as

CorneaDry Eye SyndromesMacrophagesOphthalmic NerveSomatostatinAnimalsDisease Models, AnimalFlow CytometryMaleMiceMice, Inbred C57BLNF-kappa BNF-kappa BpasireotideSomatostatin

Identifiers

PMID41201292
PMCPMC12603962

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.