Evidence map›Paper›PMID 41201539›Full record

ReviewStem cell reviews and reports2026

Advances and Challenges in Constructing Bone Organoids Using Cells Derived from Human Pluripotent Stem Cells: A Review.

Zhengyang Xie, Maoying Liu, Shaodong Wang, Ting Meng, Hong Zou, Yian Guan, Yameng Song, Yirong Kong, Liying Qin, Chuan Zhang and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhengyang Xie *School and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Maoying Liu *School of Basic Medical Sciences, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Shaodong Wang *School and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Ting MengSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Hong ZouSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Yian GuanSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Yameng SongSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Yirong KongSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China.
Liying QinSchool of Stomatology, Gansu Health Vocational College, No.1666 Jiulongjiang Street, Gaolan County, Lanzhou, 730207, P. R. China.
Chuan ZhangGansu Clinical Medical Research Center of Default Defects and Rare Diseases, Gansu Provincial Maternity and Child Care Hospital, Gansu Provincial Central Hospital, Lanzhou, 730050, P. R. China. zhangchuan0404@163.com.
Rui ZhangSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China. zhangrui@lzu.edu.cn.
Ping ZhouSchool and Hospital of Stomatology, Lanzhou University, No.222 Tianshui South Road, Chengguan District, Lanzhou, Gansu Province, 730000, P. R. China. zhoup@lzu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities zujbky-2025-30Lanzhou Science and Technology Project No.2025-2-151National Natural Science Foundation of China Regional Program No. 82560331the CSA West China Clinical Research Fund No. CSA-W2024-11the Gansu Province Health Industry Research Project GSWSQNPY2025-19the Gansu Province Health Industry Research Project No. GSWSKY2023-71the Lanzhou University Hospital of Stomatology Research Support Fund No. Izukqky-2023-t07the Natural Science Foundation of Gansu Province No. 24JRRA945the Natural Science Foundation of Gansu Province No. 24JRRA948the Natural Science Foundation of Gansu Province No. 25JRRA1236
6 · The paper itself

Abstract

Bone organoids mimic the structure and function of actual bone tissue and serve as novel tools for disease modeling, drug testing, and bone repair. However, their development is severely impeded by the limited availability of cell sources. Fortunately, human pluripotent stem cells (hPSCs) can differentiate into organoid constituent cells, including osteoblasts, osteoclasts, and endothelial cells. However, their differentiation efficiencies are relatively low and do not meet the requirements of clinical applications because of the use of undefined culture components such as fetal bovine serum. More importantly, nearly all the existing scaffolds cannot support the culture of hPSCs. Thus, much effort should be made to construct bone organoids using cells induced from hPSCs. This review starts with the in vivo development of bone tissue. We summarize the mechanisms, methods, and purification processes for differentiating hPSCs into the above cell types in bone organoids. On this basis, we described strategies related to hPSC-based bone organoids and the growth factors and bioactive materials needed to accelerate this process. Finally, we extensively discuss the existing challenges and prospects. This review is valuable for the future development and clinical application of hPSC-derived bone organoids.

Indexed as

Bone and BonesOrganoidsPluripotent Stem CellsTissue EngineeringAnimalsCell DifferentiationHumansOsteoblastsOsteogenesisBone organoidsBone tissue engineeringCell differentiationHuman pluripotent stem cells

Identifiers

PMID41201539

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.