ReviewDiscover oncology2025
Association between weight loss and survival outcomes in patients with colorectal cancer: a meta-analysis.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of postoperative delayed bowel function recovery with weight and muscle loss at 6 months in colorectal cancer patients.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundWeight reduction is a common clinical feature observed in patients with colorectal cancer and often reflects underlying tumor burden or nutritional status. This meta-analysis aims to systematically synthesize existing evidence on the relationship between weight loss and survival outcomes in patients with colorectal cancer.
methodsAn exhaustive literature search was conducted in PubMed, Embase, and Web of Science, covering all records from the inception of each database through May 15, 2025. Inclusion criteria focused on studies reporting quantitative associations between weight loss and overall survival, progression-free survival, and colorectal cancer-specific mortality in patients with colorectal cancer. For the meta-analytic synthesis, adjusted hazard ratios (HR) with 95% confidence intervals (CI) were pooled using a random-effects model.
resultsThirteen eligible studies involving 17,606 colorectal cancer patients were identified. Pooled estimates derived from random-effects modeling indicated that weight loss was significantly associated with shorter overall survival (HR 2.02; 95% CI 1.67-2.44) and progression-free survival (HR 1.34; 95% CI 1.14-1.58). Additionally, weight loss was linked to an increased risk of colorectal cancer-specific mortality (HR 3.27; 95% CI 1.75-6.12). Subgroup analyses revealed notably reduced overall survival among patients aged over 60 years (HR 2.94; 95% CI 2.45-3.53) and those experiencing weight loss of 10% or more (HR 3.19; 95% CI 2.58-3.93), compared to their counterparts.
conclusionsWeight loss is a significant and independent prognostic indicator of reduced survival in patients with colorectal cancer. Further rigorous prospective studies are needed to confirm these findings and to investigate the potential underlying biological mechanisms.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.