Evidence map›Paper›PMID 41201723›Full record

ArticleProbiotics and antimicrobial proteins2026

Effects of Lactobacillus Acidophilus Mediated Improvement of Intestinal Barrier in Mice with Autism.

Yong Song, Jia Shi, XiaoYi Fu, Dan Fu, Li Xu, WeiMei Liu, JingJing Cao, YaoCheng Ding, ShuPeng Huang, Lin Zhou and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yong SongMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
Jia ShiMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
XiaoYi FuMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
Dan FuMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
Li XuJiangxi Chengge Biotechnology Co, Yichun, 336000, Jiangxi, China.
WeiMei LiuJiangxi Chengge Biotechnology Co, Yichun, 336000, Jiangxi, China.
JingJing CaoMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
YaoCheng DingMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
ShuPeng HuangMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
Lin ZhouMedical College of YiChun University, YiChun, 336000, Jiangxi, China.
Kai QianMedical College of YiChun University, YiChun, 336000, Jiangxi, China. kaiqian_bio@126.com.

Funding

Science and Technology Project of Jiangxi Provincial Education Department GJJ2401615and JXJG-24-15-15
6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) involves complex neurodevelopmental interactions between the gastrointestinal tract, gut microbiota, and brain function. Growing evidences implicated that bidirectional microbiota-gut-brain axis signaling in ASD pathophysiology. This study examines how Lactobacillus acidophilus (ATCC-4356) alters behavioral phenotypes in a valproic acid-induced maternal immune activation (MIA) mouse model of autism. The MIA model was intraperitoneally injected with valproic acid, while controls were intraperitoneally injected with saline. Behavioral testing showed that repetitive, stereotyped, anxiety-like, and social behaviors were significantly improved (P < 0.05) after L. acidophilus (ATCC-4356) intragastric administration for seven weeks. Western blot analysis demonstrated that tight junction proteins (Claudin 1, Claudin 3, Occludin, and ZO) were highly expressed in the L. acidophilus (ATCC-4356) group versus the autism model (P < 0.05), suggesting enhanced intestinal barrier integrity. Inflammatory factor concentrations in both colon and hippocampus were markedly reduced in the L. acidophilus (ATCC-4356) group (P < 0.05). Gut microbiota sequencing showed significant increases of microbial diversity and richness in the L. acidophilus (ATCC-4356) group (P < 0.05). Hippocampal immunofluorescence revealed higher NeuN-, Ki67-, and BrdU-positive cell counts in the L. acidophilus (ATCC-4356) group (P < 0.05). Results suggest that L. acidophilus (ATCC-4356) ameliorates autistic-like behaviors, potentially through modulation of intestinal barrier function. Furthermore, results showed that therapeutic efficacy was reduced by L. acidophilus (ATCC-4356) in autism after antibiotic-induced dysbiosis of the intestinal microbiota In this paper, the results showed that L. acidophilus (ATCC-4356) improves autism-like behaviors by modulating gut barrier function.

Indexed as

Autistic DisorderIntestinal MucosaLactobacillus acidophilusProbioticsAnimalsDisease Models, AnimalFemaleGastrointestinal MicrobiomeHippocampusMaleMiceMice, Inbred C57BLAutism spectrum disorderGut microbiotaLactobacillus acidophilusMicrobiota-gut-brain axis

Identifiers

PMID41201723

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.