ReviewCurrent medical science2025
Tryptophan Metabolism in Obesity: Pathways, Mechanisms, and Therapeutic Perspectives.
Review in Current medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Plasma Aryl Hydrocarbon Receptor Agonist Activity Is Associated With Inflammation and Metabolic Dysregulation in Obesity: A Cross-Sectional Study.Diabetes/metabolism research and reviews · 2026Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a common noncommunicable disease characterized by persistent low-grade chronic inflammation and is associated with various metabolic disturbances, including insulin resistance and diabetes. The search for effective obesity treatments has led to growing interest in the role of amino acids in metabolic regulation. Tryptophan (TRP), an essential amino acid, participates in several biological pathways, including the kynurenine, 5-hydroxytryptamine (5-HT, also known as serotonin), and indole pathways. Recent evidence underscores the significance of TRP metabolism in obesity, showing that various metabolites and enzymes in its metabolic pathways are altered in individuals with obesity. These changes influence physiological processes, mood regulation, and overall metabolic health. This review provides a comprehensive overview of TRP metabolism. It highlights the potential of targeting TRP metabolism as a therapeutic strategy for managing obesity and its related metabolic and psychological comorbidities.
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Identifiers
41201781What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.