ArticleScience advances2025
NAD
Abstract read
In one paragraph
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Reprogramming Neuroinflammation: Mitochondrial Targets and Immune Checkpoint Inhibitors in Alzheimer's Disease.Molecular neurobiology · 2026Review
- The Role of the Ketogenic Diet in Modulating Biochemical Pathophysiology in Psychiatric and Neurodegenerative Disorders.International journal of molecular sciences · 2026Review
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Decoding the functions of nuclear speckles in neurodegeneration.Trends in neurosciences · 2026Review
- Article
- NADAutophagy · 2026Article
- From autophagy-lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders.Frontiers in neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Ruixue AiDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.ORCID 0000-0001-9870-3692
Lipeng MaoDepartment of Oncology, The First Affiliated Hospital, School of Medicine, Jian University, 510632 Guangzhou, China.ORCID 0000-0002-0629-0307
Xurui JinMindrank AI Ltd., Hangzhou, China.
Carlos Campos-MarquesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-0612-4333
Shi-Qi ZhangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.ORCID 0000-0001-9751-7652
Junping PanDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Maria Jose Lagartos-DonateDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Shu-Qin CaoDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.ORCID 0000-0002-4361-8308
Beatriz Barros-SantosLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-5056-1629
Rita Nóbrega-MartinsLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-1364-6404
Filippos KatsaitisLaboratory of Brain Exosomes and Pathology - ExoBrain, Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos," T. Patriarchou Grigoriou & Neapoleos, 15310 Athens, Greece.ORCID 0009-0009-0183-1045
Guang YangBioengineering Department and Imperial-X, Imperial College London, London W12 7SL, UK.ORCID 0000-0001-7344-7733
Chenglong XieDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang, China.
Xiongbin KangGenome Data Science, Faculty of Technology, Bielefeld University, Bielefeld, Germany.ORCID 0000-0001-6946-4290
Pingjie WangDepartment of Geriatrics, The First Affiliated Hospital, Zhengzhou University, 450052 Zhengzhou, China.ORCID 0000-0002-3447-754X
Manuele NovelloDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.ORCID 0000-0002-3622-3092
Yang HuDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, 510632 Guangzhou, China.ORCID 0000-0002-8291-3182
Linda Hildegard BergersenBrain and Muscle Energy Group-Preclinical Laboratories, University of Oslo, 0316 Oslo, Norway.ORCID 0000-0002-9964-9744
Jon Storm-MathisenDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, NO-0317 Oslo, Norway.ORCID 0000-0002-2930-3262
Hidehito KuroyanagiDepartment of Biochemistry, University of the Ryukyus Graduate School of Medicine, Ginowan, Okinawa 901-2720, Japan.ORCID 0000-0002-1563-1134
Beatriz Escobar-DoncelDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.ORCID 0009-0007-7176-9940
Noemí Villaseca GonzálezFaculty of Pharmacy and Biomedicine Institute, University of Castilla-La Mancha, 02008 Albacete, Spain.ORCID 0000-0003-2542-9463
Farrukh Abbas ChaudhryDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, NO-0317 Oslo, Norway.ORCID 0000-0002-2039-9667
Zeyuan WangCollege of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China.ORCID 0000-0002-5036-9602
Qiang ZhangCollege of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China.ORCID 0000-0003-1636-5269
Guang LuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-2268-1033
Ioannis SotiropoulosLaboratory of Brain Exosomes and Pathology - ExoBrain, Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos," T. Patriarchou Grigoriou & Neapoleos, 15310 Athens, Greece.ORCID 0000-0003-0115-0038
Zhangming NiuMindrank AI Ltd., Hangzhou, China.ORCID 0000-0002-7009-946X
Guobing ChenGuangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, 510632 Guangzhou, China.ORCID 0000-0002-2401-6168
Rajeevkumar Raveendran NairKavli Institute for Systems Neuroscience, NTNU, Fred Kavli-bygget, Olav Kyrres gate 9,7030 Trondheim, Norway.ORCID 0000-0001-9755-0874
Joana Margarida SilvaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-8257-3413
Oscar Junhong LuoDepartment of Oncology, The First Affiliated Hospital, School of Medicine, Jian University, 510632 Guangzhou, China.ORCID 0000-0002-1266-3069
Evandro Fei FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.ORCID 0000-0003-0355-7202
Funding
NIA NIH HHS R01 AG069941Wellcome Trust
Abstract
Dysfunctional alternative splicing events (ASEs) in RNA are markers of aging and Alzheimer's disease (AD). As a key neuronal resilience metabolite, the oxidized nicotinamide adenine dinucleotide (NAD
Indexed as
Alternative SplicingAlzheimer DiseaseNADAgedAnimalsDisease Models, AnimalFemaleHippocampusHumansMaleMiceNAD
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.