ArticleNature communications2025
Physical activity levels may impact on the risk of premature mortality in people with epilepsy.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interpretable and explainable artificial intelligence for wearable sensor-based fall risk assessment in older adults: a systematic review with considerations for prosthetics and orthotics.Frontiers in computational neuroscience · 2026Pooled it
- Wearable sensor-derived continuous physical activity dimensions and all-cause mortality in adults with diabetes and hypertension: insights from two population-based accelerometry cohorts.Acta diabetologica · 2026Article
- Site-specific pain dynamics: associations between accelerometer-measured physical activity patterns and pain in older adults.The journal of headache and pain · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Epilepsy affects over 70 million individuals worldwide, with optimal physical activity (PA) levels remaining challenging to determine due to potential negative outcomes from both insufficient and excessive activity. To quantify the associations between objective PA and mortality in people with epilepsy, we analyzed accelerometer data from 98,561 UK Biobank participants, including 1167 with epilepsy, to quantify associations between objectively measured PA and mortality. During a median follow-up of 7.1 years, people with epilepsy had significantly higher mortality rate (Standardized mortality ratio: 2.39, 1.97-2.86). Higher sedentary behavior duration was associated with lower all-cause mortality (hazard ratio: 0.87, 0.78-0.97). Dose-response analyses identified sedentary durations of 7-13 h/day (p nonlinear=0.025) and moderate-to-vigorous PA of 0.1-0.2 h/day (p nonlinear=0.005) were associated with lower mortality. An explainable machine-learning model that combined multi-dimensional PA with demographic and health information effectively stratified individual risk (Area Under the Receiver Operating Characteristic curve: 0.87 ± 0.08) and could support personalized activity guidance through a wearable system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.