Evidence map›Paper›PMID 41204039›Full record

ArticleMolecular neurobiology2025

Orphan Receptor GPRC5B Controls Adult Hippocampal Neurogenesis and Affects Retinoic Acid-Mediated Behaviors.

Wenqi Fu, Rana Alabdali, Alireza Mousaei, Fernanda Daher, Nina Wettschureck, David M MacLean, Manoela V Fogaça, Cesare Orlandi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenqi FuDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Rana AlabdaliDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Alireza MousaeiDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Fernanda DaherDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Nina WettschureckDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
David M MacLeanDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Manoela V FogaçaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Cesare OrlandiDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA. cesare_orlandi@urmc.rochester.edu.

Funding

Acid-Sensing Ion Channel gating: Conformations and ConsequencesR35GM137951 · NIGMS · UNIVERSITY OF ROCHESTER · PI David Malcolm MacLean · 2020 to 2026
$2.8M
Cortical GABAergic mechanisms underlying rapid and sustained antidepressant responsesR00MH126098 · NIMH · UNIVERSITY OF ROCHESTER · PI FOGACA, MANOELA · 2023 to 2025
$730k
Orphan Receptor Gprc5b in Retinoic Acid-induced Affective BehaviorsR03TR003621 · NCATS · UNIVERSITY OF ROCHESTER · PI ORLANDI, CESARE · 2022 to 2022
$154k
NCATS NIH HHS R03 TR003621NCATS NIH HHS R03TR00362101A1NIGMS NIH HHS R35 GM137951NIGMS NIH HHS R35GM137951NIMH NIH HHS R00 MH126098NIMH NIH HHS R00MH126098
6 · The paper itself

Abstract

Understudied orphan GPCRs lack identified natural ligands, yet understanding their function is critical for therapeutic development. GPRC5B is a brain-enriched, retinoic acid (RA)-induced orphan GPCR. While RA is used to treat severe acne, chronic exposure is associated with depression, likely due to its inhibition of adult hippocampal neurogenesis. Here, we tested whether GPRC5B plays a role in the molecular and cellular mechanisms underlying RA-induced depressive-like behaviors in mice by suppressing adult hippocampal neurogenesis. We found that Gprc5b knockout (KO) mice were resilient to RA-induced behavioral effects and that RA increased GPRC5B expression in the hippocampal neurogenic subgranular zone. This correlated with RA-mediated inhibition of adult hippocampal neurogenesis, an effect absent in Gprc5b KO mice, which also exhibited a larger pool of proliferative neuronal stem cells. Collectively, these findings suggest that GPRC5B mediates RA-induced anti-neurogenic effects and depressive-like behaviors.

Indexed as

Behavior, AnimalHippocampusNeurogenesisReceptors, G-Protein-CoupledTretinoinAnimalsDepressionMaleMiceMice, Inbred C57BLMice, KnockoutNeural Stem CellsReceptors, G-Protein-CoupledTretinoinAdult neurogenesisG protein‐coupled receptor (GPCR)Major depressive disorderMouse behaviorOrphan GPCRRetinoic acid (RA)

Identifiers

PMID41204039
PMCPMC12594696

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.