Evidence map›Paper›PMID 41204244›Full record

SynthesisBMC pediatrics2025

Association between prenatal vitamin D supplementation and respiratory diseases in children: a systematic review and meta-analysis.

Jieru Shen, Zhonghui Zhou, Fao Feng, Yu Zhang, Sayu Bao, Yangrong Feng

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jieru ShenDepartment of Respiratory, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, No.819, Liyuan North Road, Haishu District, Ningbo, 315010, China.
Zhonghui ZhouDepartment of Respiratory, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, No.819, Liyuan North Road, Haishu District, Ningbo, 315010, China.
Fao FengSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yu ZhangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Sayu BaoInternal Medicine of Traditional Chinese Medicine, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, 315010, China.
Yangrong FengDepartment of Respiratory, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, No.819, Liyuan North Road, Haishu District, Ningbo, 315010, China. 18258786733@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunomodulation and respiratory health have a critical role in the offspring well-being. Maternal status of vitamin D during pregnancy seems to have immunomodulatory and respiratory protective effects in children. However, evidence regarding respiratory and allergy-related outcomes remains conflicting. Therefore, this study aimed to synthesize the available data in this regard to provide a firm direction.

methodsComprehensive searches were made in the databases of PubMed, Scopus, the Web of Science, and the Cochrane Library until August 2025. We included randomized controlled trials (RCTs) to evaluate the effects of maternal intake of vitamin D during pregnancy on outcomes in children with respiratory and allergy conditions. Also, the quality of evidence was evaluated using GRADE method and the Cochrane risk-of-bias tool was used to evaluate study quality.

resultsSeven RCTs were included. Prenatal supplementation of vitamin D did not affect respiratory outcomes in the children who followed: RTI (RR: 1.04; 95% CI: 0.99, 1.09; P = 0.122, I

conclusionOverall, the vitamin D supplementation during pregnancy has no significant effect on respiratory and allergy-related outcomes in children.

Indexed as

Dietary SupplementsPrenatal CareRespiratory Tract DiseasesVitamin DVitaminsChildChild, PreschoolFemaleHumansHypersensitivityPregnancyRandomized Controlled Trials as TopicVitamin DVitaminsMeta-analysisRespiratory outcomeSystematic reviewVitamin d

Identifiers

PMID41204244
PMCPMC12595615

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.