Evidence map›Paper›PMID 41204250›Full record

ReviewEpigenetics & chromatin2025

DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues.

Meng-Yue Fang, Shi-Wei Liu, Prasanna R Kolatkar, Ping Qi, Yue-Chen Liu, Fei Sun, Cong-Yi Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epigenetics & chromatin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meng-Yue FangDepartment of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shi-Wei LiuTongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province, Taiyuan, China.
Prasanna R KolatkarThe Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar.
Ping QiDepartment of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yue-Chen LiuDepartment of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fei SunDepartment of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. phil_sunfei@163.com.
Cong-Yi WangTongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province, Taiyuan, China. cwang@hbku.edu.qa.

Funding

QBRI, Hamad Bin Khalifa University the IGP Fundingthe Continuous Funding Program for High-Level Research Achievements at Shanxi Bethune Hospital 2024GSPYJ10the National Key R&D Program of China 2022YFA0806101the National Natural Science Foundation of China 82130023the Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0507302the Research and Innovative Team Project for Scientific Breakthroughs at Shanxi Bethune Hospital 2024AOXIANG03
6 · The paper itself

Abstract

The expansion of adipose tissue during obesity results in alterations in the expression of adipose-derived hormones or factors, which control whole-body energy metabolism. Epigenetics refers to the heritable modifications in gene function that arise without changes in DNA sequence and are sculped by environmental factors, lifestyles, and nutritional variables. DNA methylation is a well-characterized epigenetic mechanism, and altered expression of adipose-derived hormones or factors is partly ascribed to alterations in DNA methylation levels or patterns. This review aims to summarize the regulatory effects of DNA methylation on the expression of adipokines and adipose factors, including leptin, adiponectin, cytokines as well as insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) under obese conditions. The feasibility of DNA methylation as a biomarker for the prediction and prognosis of obesity and type 2 diabetes (T2D) would be also discussed.

Indexed as

AdipokinesAdipose Tissue, WhiteDNA MethylationAdiponectinAnimalsDiabetes Mellitus, Type 2Epigenesis, GeneticHumansLeptinObesityAdipokinesAdiponectinLeptinAdipokinesAdipose factorsAdipose tissueDNA methylationObesity

Identifiers

PMID41204250
PMCPMC12593898

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.