ReviewStem cell research & therapy2025
Exploring the potential of stem cells from the apical papilla (SCAPs) in regenerative medicine: advantages, applications, challenges and opportunities.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Promise and Challenges of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Periodontal Disease.Pathogens (Basel, Switzerland) · 2026Review
- Regenerative Endodontic Procedure (REP) of a Previously Treated, Infected, Immature Permanent Incisor.Case reports in dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Stem cells from the apical papilla (SCAPs) represent a unique population of mesenchymal stem cells (MSCs) located in the apical papilla of immature permanent teeth. These cells exhibit essential MSC characteristics, including specific marker expression, self-renewal, proliferation, migration, multipotent differentiation, and immunosuppressive properties. Additionally, SCAPs secrete bioactive factors that promote tissue regeneration, making them promising candidates for stem cell-based therapies. Their regenerative potential encompasses diverse applications in dentistry, bone repair, neural regeneration, and vascular engineering, thereby positioning SCAPs as a versatile tool in regenerative medicine. However, challenges such as phenotypic instability during long-term culture and inconsistent regenerative outcomes impede their clinical translation. Addressing these challenges is crucial for advancing the clinical application of SCAPs. This review examines the advantages and therapeutic applications of SCAPs, identifies barriers to their clinical implementation, and highlights opportunities for optimizing their efficacy. By synthesizing current knowledge and proposing future research directions, this work aims to facilitate the development of SCAP-based strategies for tissue repair, bridging the gap between laboratory research and clinical practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.