Evidence map›Paper›PMID 41205028›Full record

ReviewGeroScience2026

Open problems in ageing science: a roadmap for biogerontology.

Angelo Talay, Aleksey V Belikov, Paul Ka Po To, Hamid H Alfatemi, Uri Alon, Joris Deelen, Collin Y Ewald, David Gems, Vera Gorbunova, Jan Gruber and 20 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Angelo TalayGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Aleksey V BelikovGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Paul Ka Po ToGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Hamid H AlfatemiGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Uri AlonDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Joris DeelenMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZC, Leiden, Netherlands.
Collin Y EwaldLaboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland.
David GemsInstitute of Healthy Ageing, University College London, London, UK.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY, 14627, USA.
Jan GruberHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sara HäggDepartment of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, Stockholm, Sweden.
John HemmingGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Steve HorvathAltos Labs, Cambridge, UK.
Alaattin KayaSchool of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA.
Caitlin J LewisLongevity Escape Velocity Foundation, Francisco, CA, USA.
Andrea B MaierDepartment of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorstsraat 7, 1081 BT, Amsterdam, Netherlands.
Maria B MarinovaThe Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA.
Graham PawelecInstitute of Immunology, University of Tuebingen, Tuebingen, Germany.
Shahaf PelegResearch Group Epigenetics, Metabolism and Longevity, Institute for Farm Animal Biology, 18196, Dummerstorf, Germany.
Suresh RattanDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Morten Scheibye-KnudsenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Tomas Schmauck-MedinaDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Vardan SaroyanGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Andrei SeluanovDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, 14627, USA.
Alexandra StolzingCentre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Ashby Rd, Loughborough, LE11 3TU, UK.
Emma TeelingSchool of Biology and Environmental Science, University College Dublin, Dublin, Ireland.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.
Todd WhiteThe Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA.
Maximilian UnfriedThe Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA.
João Pedro de MagalhãesGenomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. jp@senescence.info.

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9M
Translational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5M
NIA NIH HHS P01 AG047200NIA NIH HHS R01 AG043930
6 · The paper itself

Abstract

The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website ( www.longevityknowledge.app ). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.

Indexed as

AgingGeriatricsGeroscienceLongevityAnimalsHumansNatural Language ProcessingAgeing and longevity scienceBiogerontologyBiology of ageingDatabaseNatural language processing

Identifiers

PMID41205028
PMCPMC13356218

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.