Evidence map›Paper›PMID 41205317›Full record

ReviewCurrent opinion in biotechnology2025

Recent innovations in cannabinoid chemistry, biology, and biosynthesis.

Felix M Hubert, Anna C Love, Tian Lan, Hannah K Bone, Bradley S Moore

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Felix M HubertCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, United States.
Anna C LoveCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, United States. Electronic address: a1love@ucsd.edu.
Tian LanCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, United States.
Hannah K BoneCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, United States.
Bradley S MooreCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, United States. Electronic address: bsmoore@ucsd.edu.

Funding

Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
Biosynthesis and biological mechanism of minor cannabinoidsR01AT012641 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEROLD CHUN, BRADLEY S MOORE · 2024 to 2026
$2.1M
Chemoenzymatic synthesis and pharmacological evaluation of designer plant meroterpenoidsF32GM150232 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOVE, ANNA CLAIRE · 2023 to 2025
$221k
NCCIH NIH HHS R01 AT012641NIGMS NIH HHS F32 GM150232NIGMS NIH HHS R01 GM085770
6 · The paper itself

Abstract

Cannabis sativa and related plants are recognized for their psychoactive and therapeutic effects due to the unique molecules they produce, including phytocannabinoids. Beyond the major phytocannabinoids Δ⁹-tetrahydrocannabinol and cannabidiol, research on 'minor cannabinoids' has revealed new biological properties, motivating alternative production methods for these low-abundance molecules. Advances in asymmetric synthetic methods have enabled access to structurally complex cannabinoids and analogs. In tandem, synthetic biology approaches, including heterologous pathway reconstruction and functionally analogous enzyme discovery, have expanded the biosynthetic toolkit, delivering rare and novel cannabinoids at increasing scale. Here, we summarize the latest insights into cannabinoid pharmacology, synthetic chemistry innovations, and engineered production strategies, underscoring how feedback across disciplines is reshaping access to and understanding of minor cannabinoids.

Indexed as

CannabinoidsCannabisSynthetic BiologyHumansCannabinoids

Identifiers

PMID41205317
PMCPMC13459093

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.