ArticleImmunity2025
Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development.
Abstract read
In one paragraph
Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.Immunology and cell biology · 2026Review
- Highlights of 2025: advances in germinal centers.Immunology and cell biology · 2026Review
- Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Immunological memory to vaccines.Immunity · 2026Review
- Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.bioRxiv : the preprint server for biology · 2026Article
- Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice.Frontiers in immunology · 2026Article
- Multimodal analysis definesbioRxiv : the preprint server for biology · 2025Article
- Modeling the Synergetic Dynamics of B cells and TbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Ester Marina-ZárateCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Henry J SuttonCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Paul G LopezCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Tasha K AltheideCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Michael BickDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Iszac BurtonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Elana Ben-AkivaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Katarzyna Kaczmarek MichaelsKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Kesha HyacinthEmory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA.
Brandon S HealyEmory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA.
Deuk LimEmory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA.
Lars HangartnerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Dennis R BurtonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; IAVI Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Diane G CarnathanConsortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA.
Guido SilvestriConsortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA.
William R SchiefDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Darrell J IrvineDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Shane CrottyCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, San Diego, CA, USA. Electronic address: shane@lji.org.
Funding
Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6MYerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MB and T Cell Biology of Protection from and Eradication of SIV/SHIV InfectionUM1AI169662 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Eric Hunter · 2022 to 2026
$32.0MViral Testing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research CenterU42OD011023 · OD · EMORY UNIVERSITY · PI Matthew Ryan Gardner · 2018 to 2026
$17.5MMaximizing germinal centers and somatic hypermutation to HIV Env immunogensR37AI125068 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Shane P Crotty, Darrell J Irvine · 2021 to 2026
$5.4MMaximizing germinal centers and somatic hypermutation to HIV Env immunogensR01AI125068 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P, IRVINE, DARRELL J · 2016 to 2020
$4.3MNIAID NIH HHS R01 AI125068NIAID NIH HHS R37 AI125068NIAID NIH HHS UM1 AI144462NIAID NIH HHS UM1 AI169662NIH HHS P51 OD011132NIH HHS U42 OD011023
Abstract
Durability of T follicular helper (Tfh) cell responses is pivotal for generating high affinity antibodies. We characterized Tfh cell responses to HIV Env immunization longitudinally in non-human primates, analyzing >500,000 CD4
Indexed as
AIDS VaccinesAntibodies, NeutralizingGerminal CenterHIV-1HIV AntibodiesHIV InfectionsT Follicular Helper CellsT-Lymphocytes, Helper-InducerAnimalsenv Gene Products, Human Immunodeficiency VirusHumansInterleukin-21Lymph NodesMacaca mulattaAIDS VaccinesAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesInterleukin-21AIDSCD4 T cellsgerminal centergerminal center B cellsHIVneutralizing antibodiessingle-cell RNA-seqTfhT follicular helper cellsvaccines
Identifiers
What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.