Evidence map›Paper›PMID 41206377›Full record

ArticleThe protein journal2026

Multi-scale In Silico and Biochemical Evaluation of Natural Bisbenzylisoquinoline Alkaloids as Aldose Reductase Inhibitors.

Emadeldin M Kamel, Noha A Ahmed, Sarah I Othman, Adil Abalkhail, Faris F Aba Alkhayl, Bassam A Abuamarah, Saleh Maodaa, Al Mokhtar Lamsabhi

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Article in The protein journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emadeldin M KamelChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.
Noha A AhmedPhysiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt. drnohascience@science.bsu.edu.eg.
Sarah I OthmanDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, 11671, Riyadh, Saudi Arabia.
Adil AbalkhailDepartment of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Faris F Aba AlkhaylDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452, Buraydah, Saudi Arabia.
Bassam A AbuamarahDepartment of Geology and Geophysics, King Saud University, 11451, Riyadh, Saudi Arabia.
Saleh MaodaaDepartment of Zoology, College of Science, King Saud University, PO Box -2455, 11451, Riyadh, Saudi Arabia.
Al Mokhtar LamsabhiDepartamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid, 28049, Madrid, Spain.

Funding

Ministerio de Ciencia, Innovación y Universidades PID2023-150717NB-I00Princess Nourah Bint Abdulrahman University PNURSP2025R5
6 · The paper itself

Abstract

Aldose reductase (AR) is the rate-limiting enzyme of the polyol pathway and a validated target for preventing micro- and neurovascular complications of diabetes. Here, we combined multi-scale in-silico analyses with biochemical testing to evaluate five commercially available bisbenzylisoquinoline alkaloids-cepharanthine, dauricine, isotetrandrine, fangchinoline and sinomenine-as potential AR inhibitors. Density-functional optimization, structure-based docking and 500 ns molecular-dynamics simulations revealed that the macrocyclic scaffolds of cepharanthine (ΔG

Indexed as

Aldehyde ReductaseAlkaloidsBenzylisoquinolinesEnzyme InhibitorsHumansMolecular Docking SimulationMolecular Dynamics SimulationAldehyde ReductaseAlkaloidsBenzylisoquinolinesEnzyme InhibitorsAlkaloidsAtomistic MDHyperglycemiaIn vitro experimentsKineticsPolyol-pathway enzyme (aldose reductase)

Identifiers

PMID41206377

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.