Trial reportClinical rheumatology2026
Health outcomes associated with patient-perceived gout aetiology: a cross-sectional analysis of the GAPP Study baseline data.
Trial report in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
Abstract
objectivesCurrent medical models of gout emphasise genetics and renal mechanisms in gout pathogenesis, in contrast to lay understanding that gout is caused by lifestyle factors. However, whether the perceived causative role of lifestyle factors contributes to sub-optimal health outcomes has not been substantiated quantitatively. This study examined the relationship between reported causes of gout and health outcomes.
methodsAs part of a larger randomised controlled trial (Trial Registration: ACTRN12616000455460), participants (n = 492) completed surveys at baseline in which they were asked to list three factors they believed caused their gout. Responses were grouped thematically and matched to participant serum urate (SU) levels, gout flare incidence, and self-reported urate-lowering therapy (ULT) adherence. Descriptive and regression analyses were performed, adjusted for age and sex.
resultsMost participants (63.4%) listed a lifestyle factor as the primary cause of their gout, most commonly diet (36.0%) or alcohol (14.4%). Fewer people reported physiological factors (28.3%), typically genetics (19.9%). Individuals who perceived gout to be primarily caused by lifestyle factors had higher concentrations of SU (β = 0.02; 95% CI: 0.01 to 0.04; p = 0.020) and lower odds of having target SU level of ≤ 0.36 mmol/L (OR = 0.64; 95% CI: 0.41 to 0.99; p = 0.043). Perceiving physiological factors as the primary cause of gout was associated with lower SU and higher odds of having target SU.
conclusionThe perception that gout is caused by lifestyle excess remains prevalent among patients and may contribute to poor SU control. Patient education as to the physiological causes of gout may support management.
trial registrationAustralian New Zealand Clinical Trials Registry (Trial Registration: ACTRN12616000455460, Date registered: 7/04/2016). Key Points • The majority of gout patients continue to perceive gout as a disease of lifestyle excess. • Perceiving gout to be caused by lifestyle factors was associated with poorer health outcomes. • Perceiving gout to have a physiological aetiology was associated with better health outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.