Evidence map›Paper›PMID 41207366›Full record

ArticleOsteoarthritis and cartilage2026

Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study.

Ryo Yoshikawa, Neil A Segal, Irina Tolstykh, Michael Ho, Donald D Anderson, John A Lynch, Jeffrey Duryea, Michael C Nevitt

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryo YoshikawaDepartment of Physical Medicine & Rehabilitation, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: ryoshikawa@kumc.edu.
Neil A SegalDepartment of Physical Medicine & Rehabilitation, University of Kansas Medical Center, Kansas City, KS, USA; Department of Epidemiology, The University of Iowa, Iowa City, IA, USA. Electronic address: nsegal@kumc.edu.
Irina TolstykhDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: Irina.Tolstykh@ucsf.edu.
Michael HoDepartment of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA. Electronic address: michael.ho@bsci.com.
Donald D AndersonDepartment of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA. Electronic address: don-anderson@uiowa.edu.
John A LynchDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: John.Lynch@ucsf.edu.
Jeffrey DuryeaDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: jduryea@bwh.harvard.edu.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: Michael.Nevitt@ucsf.edu.

Funding

Project 3: Intraarticular MineralizationU19AG076471 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2023 to 2026
$49.0M
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Accelerating Osteoarthritis Clinical Trials Through Responsive Low-Dose Standing CT ImagingR01AR071648 · NIAMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SEGAL, NEIL A · 2018 to 2020
$607k
NIAMS NIH HHS R01 AR071648NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U19 AG076471
6 · The paper itself

Abstract

objectiveThis study compared the predictive validity of three-dimensional joint space width (3D-JSW) on weight-bearing computed tomography (WBCT) versus two-dimensional joint space width at predetermined mediolateral locations (2D-JSW

designData from 302 participants (425 knees) in the Multicenter Osteoarthritis Study (MOST) were analyzed. Baseline assessments included bilateral standing radiographs for 2D-JSW

resultsParticipants had a mean age of 63.2±8.9 years and body mass index (BMI) of 28.2±4.8 kg/m². Over 24 months, 38 knees exhibited worsening WOMAC pain, with no significant association for either 3D-JSW or 2D-JSW

conclusions3D-JSW on WBCT did not outperform 2D-JSW

Indexed as

ArthralgiaKnee JointOsteoarthritis, KneeTomography, X-Ray ComputedAgedDisease ProgressionFemaleHumansImaging, Three-DimensionalMaleMiddle AgedPain MeasurementPredictive Value of TestsWeight-BearingCone beam computed tomographyDiagnostic imagingKneeOsteoarthritisPainPhysical function

Identifiers

PMID41207366
PMCPMC12629503

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.