Evidence map›Paper›PMID 41207626›Full record

ArticleThe Journal of biological chemistry2025

The scaffold protein IQGAP1 regulates the epithelial Na

Louise Thines, Shujie Shi, Samar Sayedyahossein, Zhigang Li, Francis J Roushar, Thomas R Kleyman, David B Sacks

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Louise ThinesDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Shujie ShiDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Samar SayedyahosseinDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Zhigang LiDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Francis J RousharDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David B SacksDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: sacksdb@mail.nih.gov.

Funding

ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 to 2025
$2.0M
Resource Development CoreU54DK137329 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$953k
Degenerin and TrpC6 channels in renal vascular mechanosesnsor signaling and protection against injury.R01DK137167 · UNIVERSITY OF MISSISSIPPI MED CTR · 2025 to 2025
$598k
Role of PON3 in regulating renal Na+ and K+ homeostasisR01DK130901 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$318k
NHLBI NIH HHS R01 HL147818NIDDK NIH HHS R01 DK130901NIDDK NIH HHS R01 DK137167NIDDK NIH HHS U54 DK137329
6 · The paper itself

Abstract

The epithelial Na

Indexed as

Epithelial Sodium Channelsras GTPase-Activating ProteinsAnimalsAquaporin 2DogsHumansMadin Darby Canine Kidney CellsMiceOocytesSodiumXenopus laevisAquaporin 2Epithelial Sodium ChannelsIQ motif containing GTPase activating protein 1ras GTPase-Activating ProteinsSodiumchannelENaCepitheliaIQGAP1kidneylungNa(+)sodium reabsorptiontraffickingXenopus oocytes

Identifiers

PMID41207626
PMCPMC12757641

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.