Evidence map›Paper›PMID 41207999›Full record

ArticleNeuroscience bulletin2026

Variations of Corticotropin-Releasing Factor Receptor 1α Contribute to the Blunted HPA Axis Responses to Hypoxia in Plateau Mammals.

Jiafang Yang, Fangyuan Xia, Hao Jin, Chatoo Mahanand, Huiqi Lin, Yibin Cao, Jianghui Bian, Dengbang Wei, Eviatar Nevo, Jizeng Du and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiafang Yang *Department of Neurology of the Second Affiliated Hospital, School of Brain Sciences and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Fangyuan Xia *Department of Neurology of the Second Affiliated Hospital, School of Brain Sciences and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Hao JinNHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, 310058, China.
Chatoo MahanandDepartment of Neurology of the Second Affiliated Hospital, School of Brain Sciences and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Huiqi LinDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yibin CaoCollege of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, 321000, China.
Jianghui BianNorthwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining, 810001, China.
Dengbang WeiState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810003, China.
Eviatar NevoInstitute of Evolution and International Graduate Center of Evolution, University of Haifa, Mount Carmel, 3498838, Haifa, Israel.
Jizeng DuDepartment of Neurology of the Second Affiliated Hospital, School of Brain Sciences and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Shumin DuanNHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, 310058, China.
Fang GuoNHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, 310058, China. gfang@zju.edu.cn.ORCID http://orcid.org/0000-0002-0433-9808
Yang ZhaoDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. yang.zhao@zju.edu.cn.ORCID http://orcid.org/0000-0002-8703-3678
Xuequn ChenDepartment of Neurology of the Second Affiliated Hospital, School of Brain Sciences and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310016, China. chewyg@zju.edu.cn.ORCID http://orcid.org/0000-0002-6105-8869

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corticotropin-releasing factor (CRF) and its receptor (CRFR1) are critical components of the hypothalamic-pituitary-adrenocortical (HPA) axis. Ochotona curzoniae (O. curzoniae), Myospalax baileyi (M. baileyi), and Microtus oeconomus (M. oeconomus) have diversely evolved adaptive strategies to the extreme environment at high altitude. Here, we found blunted HPA axis responsiveness in native Tibetan mammals. CRF was 100% conserved, three amino-acid variations were in M. oeconomus-urocortin (UCN), and unique amino-acid variations in ligand-receptor binding domains of O. curzoniae-, M. baileyi-, and M. oeconomus-CRFR1αs. The native mammals' binding affinity and cAMP production varied depending on different doses of ligand-CRF/UCN treatment. Variations in M. oeconomus-UCN and O. curzoniae-, M. baileyi-, M. oeconomus-CRFR1α were responsible for weaker CRF-CRFR1α binding and higher EC

Indexed as

Hypothalamo-Hypophyseal SystemHypoxiaPituitary-Adrenal SystemReceptors, Corticotropin-Releasing HormoneAnimalsCorticotropin-Releasing HormoneCRF Receptor, Type 1Cyclic AMPHumansMaleCorticotropin-Releasing HormoneCRF Receptor, Type 1Cyclic AMPReceptors, Corticotropin-Releasing HormonecAMPCRFCRFR1αExtreme environmentHPAStress

Identifiers

PMID41207999
PMCPMC13388585

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.