Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Accelerated biological aging and midlife frailty among U.S. military veterans.
Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Deficit accumulation frailty and risk of incident chronic kidney disease: a prospective analysis of the UK biobank and CHARLS cohorts.International urology and nephrology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Injuries characterizing recent military service, such as traumatic brain injury and posttraumatic stress disorder, are linked to accelerated biological aging. If recent veterans have accelerated aging, they might also show early onset of aging-related phenotypes, such as frailty. In this study, we examined the prevalence of frailty and associations with biological aging using data from 1,654 post-9/11 veterans, who were followed for an average of 12.6 years. Biological aging was assessed using DunedinPACE, and frailty was assessed using 11 years of Jen Frailty Index scores from electronic health records. We found a high proportion of frailty-25.5% of post-9/11 veterans met frailty criteria during the study. This is roughly double the prevalence among community-dwelling older adults, despite the cohort's average age of 50.2 years at study end. Veterans with faster aging had higher initial frailty scores (β, 0.21; 95% CI, 0.15-0.27), higher peak frailty scores (β, 0.24; 95% CI, 0.18-0.30), and larger increases in frailty scores over time (β, 0.15; 95% CI, 0.09-0.21, all ps < .001). Faster aging was associated with a 62% (95% CI, 44%-82%) greater rate of incident frailty over the follow-up, while accounting for demographics, baseline health, and smoking. These results suggest post-9/11 veterans are at risk of early onset frailty, and this increased risk could be explained by accelerated rates of biological aging. Future research should replicate these results in nationally representative samples of post-9/11 veterans and explore whether screening for frailty should be implemented at younger ages for veterans.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.