Evidence map›Paper›PMID 41208150›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Photo-Empowered Macrophage-Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery.

Zhaoming Fu, Xin Cui, Shanshan Liu, Lu Gao, Yingang Sun, Yujun Chen, Mianlong Li, Yuxin Fan, Jing Kuang, Wen Song and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhaoming FuState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Xin CuiState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Shanshan LiuState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Lu GaoState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Yingang SunState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Yujun ChenState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Mianlong LiState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Yuxin FanState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.
Jing KuangInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wen SongState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.ORCID https://orcid.org/0000-0001-8225-5370
Feifan ZhouState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, 572025, China.

Funding

Hainan Province Key Area R&D Program ZDYF2024SHFZ068Hainan Provincial Natural Science Foundation Innovation Research Team Program 825CXTD609National Natural Science Foundation of China 22365014National Natural Science Foundation of China 82171990
6 · The paper itself

Abstract

Recently, cell-based drug delivery systems emerge as highly promising alternatives in the field of antitumor therapy. These systems are characterized by their excellent biocompatibility, robust drug-loading capacity, and the ability to effectively traverse biological barriers. However, the immunosuppressive tumor microenvironment significantly weakens the motility of immune cells, which is crucial for efficient drug delivery. A novel photo-empowered macrophage-based (PEM) drug delivery system is successfully developed in this study. The system is modified with thylakoids extracted from spinach leaves. Upon stimulation with light of specific wavelengths, the thylakoids generate ATP through photochemical reactions, thereby significantly enhancing the motility of macrophages and effectively overcoming the limitations imposed by the tumor microenvironment. In this work, the PEM system is loaded with two antitumor drugs: doxorubicin (Dox) and tirapazamine (TPZ). The results demonstrate that the system not only significantly improves the delivery efficiency of drugs to deep tumor tissues but also greatly enhances antitumor therapeutic efficacy. Particularly after deep infiltration into tumor tissues, the PEM system efficiently eradicates hypoxic and drug-resistant tumor cells, showcasing remarkable performance. This innovative PEM strategy provides a new approach for deep tumor drug delivery and addressing multidrug resistance, holding great promise for a significant breakthrough in antitumor therapy.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsMacrophagesNeoplasmsAnimalsCell Line, TumorDoxorubicinHumansMiceMice, Inbred BALB CTirapazamineTumor MicroenvironmentAntineoplastic AgentsDoxorubicinTirapazamineATPdeep tumor drug deliverymetabolic suppressionmotilityphoto‐empowerment

Identifiers

PMID41208150
PMCPMC12850126

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.