Evidence map›Paper›PMID 41208434›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026

Protein Kinase C Regulates Meiosis in Mammalian Oocytes.

Jaroslav Kalous, Fatima J Berro, Lucie Nemcova

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Protein Kinase C Regulates Meiosis in Mammalian Oocytes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jaroslav KalousLaboratory of Biochemistry and Molecular Biology of Germ Cells, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Rumburska 89, 27721, Libechov, Czech Republic.ORCID https://orcid.org/0000-0002-0270-7144
Fatima J BerroLaboratory of Biochemistry and Molecular Biology of Germ Cells, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Rumburska 89, 27721, Libechov, Czech Republic.
Lucie NemcovaLaboratory of Developmental Biology, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Rumburska 89, 27721, Libechov, Czech Republic.

Funding

Czech Science Foundation 22-27301SInstitutional Research Concept RVO67985904
6 · The paper itself

Abstract

The protein kinase C (PKC) family comprises enzyme kinases that regulate cell survival, metabolism, and proliferation. PKC isotypes (PKCs) phosphorylate specific downstream substrates, thereby controlling critical steps in both mitotic and meiotic cell division. Throughout the cell cycle, PKCs orchestrate essential processes, such as chromosome segregation, recombination, and cell cycle progression. In vertebrates, PKCs play essential roles in oogenesis and the early stages of embryo development. Disruption of PKC signaling in mammalian oocytes can lead to errors in chromosome segregation and induce meiotic arrest. Therefore, investigating PKC function in meiosis is crucial for advancing fundamental biological research and for developing new approaches to infertility treatment.

Indexed as

MeiosisOocytesProtein Kinase CAnimalsChromosome SegregationFemaleHumansMammalsOogenesisSignal TransductionProtein Kinase Cearly embryomeiosisoocytesprotein kinase Cspindle

Identifiers

PMID41208434
PMCPMC12822854

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.