Impact of acute and chronic hypoxia on the heme oxygenase/carbon monoxide pathway in naked mole-rats (Heterocephalus glaber).

Kristi M Kezar, Liam Eaton, Karen L Kadamani, Mohammad Ojaghi, Leo E Otterbein, Matthew E Pamenter, Michael S Tift

Abstract read

In one paragraph

Article in The Journal of experimental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

IGF-mediated glucose signalling is retained in adult naked mole-rats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristi M KezarDepartment of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC 28403, USA.

Liam EatonDepartment of Biology, University of Ottawa, Ottawa, ON, CanadaK1N 9A7.

Karen L KadamaniDepartment of Biology, University of Ottawa, Ottawa, ON, CanadaK1N 9A7.

Mohammad OjaghiDepartment of Biology, University of Ottawa, Ottawa, ON, CanadaK1N 9A7.

Leo E OtterbeinDivision of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Center for Life Sciences, Harvard Medical School, Boston, MA 02215, USA.

Matthew E PamenterDepartment of Biology, University of Ottawa, Ottawa, ON, CanadaK1N 9A7.

Michael S TiftDepartment of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC 28403, USA.ORCID 0000-0002-0563-0509

Funding

Canada Excellence Research Chairs, Government of CanadaCanada Research ChairDivision of Integrative Organismal Systems 1927616Hamilton CompanyHamilton Company Pipette Grant and Syringe Product GrantNational Football League Players AssociationNational Science Foundation 1927616Natural Sciences and Engineering Research Council of Canada 2020-07119NSERC Discovery Grant #2020-07119Players Association of the National Football LeagueUniversity of North Carolina Wilmington Parnell Award

6 · The paper itself

Abstract

Heme oxygenase (HO) enzymes are responsible for the degradation of free heme and producing endogenous carbon monoxide (CO). Research has suggested that the HO-CO pathway imparts protective effects to hypoxic tissues. The objective of this study was to investigate the effects of acute (4 h or 24 h at 7% O2) and chronic (7 days at 11% O2) hypoxia on the HO-CO pathway in the hypoxia-tolerant naked mole-rat. Specifically, we measured CO concentrations in nine organs and blood, as well as HO activity in all organs of animals exposed to normoxia (21% O2), acute hypoxia or chronic hypoxia. Hypoxia did not impact CO concentration or HO activity in most tissues, with the exception of the brain (decreased [CO] after 24 h and 7 days), heart (increased HO activity after 4 h), and intestine (increased [CO] after 24 h and 7 days but decreased HO activity after 24 h). Relative to normoxic controls, hemoglobin concentrations increased 10-12% in animals exposed to acute hypoxia but were unchanged following chronic hypoxia. In naked mole-rats exposed to normoxia or hypoxia, CO concentrations were higher in blood, lung and spleen, and HO activity was higher in the kidney and lung when compared with tissues from mice exposed to normoxia. However, splenic HO activity was higher in mice exposed to normoxia when compared with spleen from naked mole-rats in all treatment conditions. Unlike non-hypoxia tolerant species, chronic hypoxia did not suppress the HO-CO pathway in naked mole-rats, highlighting the importance of this pathway in hypoxia physiology.

Indexed as

Carbon MonoxideHeme Oxygenase (Decyclizing)HypoxiaMole RatsAnimalsHemoglobinsMaleCarbon MonoxideHeme Oxygenase (Decyclizing)HemoglobinsCarbon monoxideCarboxyhemoglobinHeme oxygenaseHypoxia toleranceNaked mole-rat

Identifiers

PMID41208449

DOI10.1242/jeb.250502

PMCPMC12752505

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.