Evidence map›Paper›PMID 41208522›Full record

ReviewEmergency medicine Australasia : EMA2025

Monoclonal Antibody Therapies in Alzheimer's Disease: A Guide for Emergency Physicians.

Scott Wrigley, Andrew L H Huynh, Sanka Amadoru, Henry Zeimer, Irene Tan, Michael Woodward, George Braitberg, Paul Andrew Yates

Abstract readReview
In one paragraph

Review in Emergency medicine Australasia : EMA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott WrigleyMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.ORCID 0000-0003-0608-1414
Andrew L H HuynhMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.
Sanka AmadoruMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.ORCID 0000-0002-0522-6143
Henry ZeimerMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.
Irene TanMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.
Michael WoodwardMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.
George BraitbergDepartment of Emergency Medicine, Austin Health, Victoria, Australia.
Paul Andrew YatesMedical and Cognitive Research Unit, Department of Geriatric Medicine, Austin Health, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whilst the advent of novel disease-modifying medications for Alzheimer's disease represents potential benefit for patients and caregivers, they may be associated with adverse events that present important considerations for emergency and primary care. This article seeks to highlight some of the challenges Emergency Departments may encounter in relation to clinical presentations of people being treated with novel anti-amyloid monoclonal antibodies in the Australian context. Given the potential for harm if not recognised and managed appropriately, it is imperative that emergency clinicians are aware of possible treatment-related adverse events and have access to appropriate decision-making support and resources.

Indexed as

Alzheimer DiseaseAntibodies, Monoclonal, HumanizedEmergency MedicineAmyloid beta-PeptidesAustraliaClinical Decision-MakingDecision Support TechniquesEmergency Service, HospitalHumansInfusions, IntravenousPractice Guidelines as TopicAmyloid beta-PeptidesAntibodies, Monoclonal, HumanizeddonanemablecanemabAlzheimer's diseaseamyloid‐related imaging abnormalities (ARIA)dementiamonoclonal antibodiesneurological deterioration

Identifiers

PMID41208522
PMCPMC12598438

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.