Evidence map›Paper›PMID 41208865›Full record

ArticleFrontiers in pharmacology2025

Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis.

San-Qiao Yang, Yu-Hui Tang, Si-Min Chen, Fen Liu, Ping Zhang, Wei Zou, Bo Wang, Xiao-Qing Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

San-Qiao YangDepartment of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Yu-Hui TangInstitute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Si-Min ChenInstitute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Fen LiuNHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, Hunan, China.
Ping ZhangNHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, Hunan, China.
Wei ZouNHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, Hunan, China.
Bo WangDepartment of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Xiao-Qing TangInstitute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We have previously demonstrated that hydrogen sulfide (H Methods: The depression model of Sprague-Dawley (SD) rats was established by CUMS for four consecutive weeks. The expressions of necroptosis-related protein and KP-related protein were evaluated by Western blotting (WB). The levels of inflammatory factors were measured by enzyme-linked immunosorbent assay (ELISA). The hippocampal metabolites of tryptophan were determined by LC-MS/MS. Results: In this study, we found that H Conclusion: The antidepressant-like role of H

Indexed as

depressionH2Skynurenine pathwaynecroptosisneuroinflammation

Identifiers

PMID41208865
PMCPMC12592148

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.