Evidence map›Paper›PMID 41208867›Full record

ArticleFrontiers in pharmacology2025

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway.

Huan Yu, Tianzhao Xu, Qiaozong Feng, Yilin Wang, Jun Zou, Xiaoyun Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huan Yu *Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Tianzhao Xu *Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Qiaozong FengShanghai Pudong New Area Hangtou Hesha Community Health Service Center, Shanghai, China.
Yilin WangShanghai University of Medicine and Health Sciences, Shanghai, China.
Jun ZouDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Xiaoyun MaShanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study investigated the protective effects of baicalin on retinal ganglion cells (RGCs) subjected to ischemia-reperfusion injury and explored the underlying mechanisms. Methods: By establishing an Results: The results demonstrated that baicalin significantly suppressed the M1 polarization of microglia, promoted their shift toward M2 polarization, and alleviated oxidative stress and ferroptosis in RGCs by inhibiting the JAK2/STAT3 signaling pathway. Conclusion: This study reveals that baicalin protects RGCs by modulating microglial polarization and inhibiting ferroptosis, providing novel insights for the treatment of glaucoma.

Indexed as

baicaliniron deathmicrogliaoxidative stressretinal ganglion cells

Identifiers

PMID41208867
PMCPMC12592121

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.