Evidence map›Paper›PMID 41208893›Full record

ArticleInternational journal of biological sciences2025

The Remodeling of Mitochondrial-Endoplasmic Reticulum Contacts by Omega-3 Fatty Acids Mitigates Dietary Advanced Glycation End Product-Driven Sertoli Cell Senescence and Oligoasthenozoospermia.

Zhaowanyue He, Feiyan Ge, Chuwei Li, Min Zang, Chun Cao, Jing Zhang, Shanshan Sun, Hong Zhang, Yijian Xiang, Yao Xu and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Zhaowanyue HeDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Feiyan GeDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Chuwei LiDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Min ZangDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Chun CaoThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China, 510515.
Jing ZhangState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Shanshan SunDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Hong ZhangDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Yijian XiangState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Yao XuState Key Laboratory of Reproductive Medicine and offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China, 211166.
Kuan LiangDepartment of Reproductive Medicine, Affiliated Jinling Hospital, Nanjing Medical University, Nanjing, China, 210002.
Yuming FengDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Zhichuan ZouDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Hui WangDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Weiqing ChenDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Jie DongDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Jinzhao MaDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Shanmeizi ZhaoDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Li ChenDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Jun JingDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Rujun MaDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Xie GeDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.
Bing YaoDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China, 210002.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary components or patterns have been shown to affect male fertility. The increasing intake of processed foods rich in advanced glycation end products (AGEs) may threaten spermatogenesis. However, the key cell type affected by AGEs in spermatogenic microenvironment remains unspecified. Furthermore, given that subcellular organelle interactions, particularly communications between mitochondria and endoplasmic reticulum (ER), are of paramount importance in male fertility, it is worthwhile to investigate dynamic changes of mitochondria-ER contacts (MERCs) in AGE-driven spermatogenesis dysfunction. In this study, we found that serum AGEs levels increased in patients with oligoasthenozoospermia (OAZ), which was accompanied by decreased inhibin B levels, leading us to explore the effect of AGEs on Sertoli cells.

Indexed as

AsthenozoospermiaDietary Advanced Glycation End ProductsFatty Acids, Omega-3OligospermiaSertoli CellsAdultAnimalsCase-Control StudiesCellular SenescenceDietary SupplementsDisease Models, AnimalEndoplasmic ReticulumHumansInhibinsMaleMiceDietary Advanced Glycation End ProductsFatty Acids, Omega-3inhibin BInhibinsAdvanced glycation end productsMale infertilityMitochondria‒endoplasmic reticulum contactsOmega-3 fatty acidsReceptor for AGESertoli cell

Identifiers

PMID41208893
PMCPMC12594550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.