ArticleFrontiers in immunology2025
Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise-mediated extracellular vesicle-derived non-coding RNAs and cardiovascular protection: mechanistic insights and bibliometric analysis.Frontiers in physiology · 2026Pooled it
- Exercise as a Programmable Regulator of Mitophagy Sensitivity in Aging Muscle and Age-Related Disease.IUBMB life · 2026Review
- Vascular integrity and immune infiltration in SCI pain: Can exercise tip the balance?Experimental neurology · 2026Article
- Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.Frontiers in immunology · 2026Review
- Impact of exercise intervention on immune function during aging.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Aging is accompanied by immunoscenescence and chronic low-grade inflammation (inflammaging), contributing to age-related diseases. Physical exercise is a potent modulator of immune function and systemic inflammation, yet the effects of acute exercise intensity on immune activation, cytokine dynamics, and extracellular vesicle release in older adults remain incompletely characterized, particularly in a sex-specific context. This study investigated how a single session of acute continuous moderate versus intense exercise modulates immune cell subsets, cytokine levels, and EV profiles in healthy older individuals, with emphasis on sex-based differences. Methods: Thirty-three older adults completed either a moderate (n=14, 54-79 years; 60% VO Resuls: Moderate exercise enhanced classical monocyte activation (↑CD86, ↓CX3CR1) without altering cell counts, and selectively elevated IL-6 in females. Intense exercise induced stronger innate immune activation, increasing classical and nonclassical monocytes, CD56 Discussion: Acute exercise modulates immune responses in an intensity- and sex-dependent manner in older adults. Extracellular vesicle release was assessed only in the high-intensity intervention, where significant changes were observed. These findings support personalized exercise regimens to enhance immune resilience and promote healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.