ReviewReviews in cardiovascular medicine2025
The Involvement of Herpesviruses in the Pathogenesis of Thoracic Aortic Aneurysms: Passive Bystanders or Active Contributors?
Review in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fundamental mechanism of thoracic aneurysm dissection involves morphological and functional reorganization of the aorta, accompanied by a reduction in the biomechanical parameters of the arterial wall. Functional zones with high receptor density are distinguished along the aorta. The autonomic reflex arc ensures the functional feasibility for a virus to penetrate the functional zones of the aorta. Numerous clinical and experimental studies demonstrated that necrotic changes specific to aneurysms develop in the middle sheath of the aorta. Therefore, necrosis of the aortic media may result from damage by the virus to the middle layer of the aorta. Further research should focus on the potential role of herpesviruses in medial vascular wall necrosis. The development of antiviral therapy for patients with aortic aneurysms will help stop medial necrosis in the aortic wall and possibly reduce mortality rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.