Management of Non-Islet Cell Tumor Hypoglycemia Induced by Adrenal Cortical Carcinoma.

Yaling Tang, Oksana Hamidi, Jessica Abramowitz, Azucena Herrera Chancay, Liwei Jia, Sadia Ali

Abstract readCase Reports

In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaling TangDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Oksana HamidiDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID https://orcid.org/0000-0002-7367-3885

Jessica AbramowitzDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID https://orcid.org/0000-0002-0391-7207

Azucena Herrera ChancayDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Liwei JiaDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Sadia AliDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID https://orcid.org/0000-0003-4458-7811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome that significantly worsens the prognosis of underlying malignancies. It is characterized by hypoglycemia resulting from ectopic production of insulin-like growth factor 2. NICTH caused by adrenal cortical carcinoma (ACC) is extremely rare. To date, no curative treatment of nonoperable NICTH has been reported. In this report, we describe a case of ACC-induced NICTH that was refractory to multiple treatments for hypoglycemia. It provides diagnostic and treatment approaches for NICTH and emphasizes the limitations of existing medical therapies for NICTH.

Indexed as

adrenal cortical carcinomaCushing syndromeinsulin-like growth factor 2non-islet cell tumor hypoglycemia

Identifiers

PMID41209155

DOI10.1210/jcemcr/luaf245

PMCPMC12596123

What Socratic holds

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