ArticleQuantitative imaging in medicine and surgery2025
Effect of age on substantia nigra subregions using neuromelanin-sensitive magnetic resonance imaging overlapping on quantitative susceptibility mapping.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The signal intensity (SI) of neuromelanin and iron concentration in substantia nigra (SN) increase with age, but may vary within the SN subregions. We aimed to investigate the effect of age on neuromelanin-sensitive magnetic resonance imaging (NM-MRI) measurements and iron concentration on quantitative susceptibility mapping (QSM) in SN subregions. Methods: A total of 95 healthy volunteers aged 18-84 years underwent NM-MRI scans using deep learning reconstruction, with and without a magnetization transfer (MT) pre-pulse, and a three-dimensional (3D) enhanced susceptibility-weighted angiography sequence that was used to construct the QSM. Two radiologists conducted manual measurements twice of the lateral, central, and medial parts of bilateral dorsal and ventral SN and cerebral peduncles (CP) using 2-mm Results: CRs (R Conclusions: Effect of age on NM-MRI measures varied across the SN subregions. The relationship between CRs and MTR in the dorsal and ventral SN as well as between CRs and QSM value in dorsal SN could be referential for pathological conditions.
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