Evidence map›Paper›PMID 41209694›Full record

ArticleMaterials today. Bio2025

Immunoregulatory electrospinning fiber mediates Macrophage energy metabolism reprogramming to promote burn wound healing.

Haoyang Wu, Qimeng Wu, Chen Liang, Jiali Hua, Lingyi Meng, Paweł Nakielski, Chenyan Lu, Filippo Pierini, Liqun Xu, Yunlong Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haoyang WuDepartment of Hypoxic Biomedicine, Institute of Special Environmental Medicine and Coinnovation Center of Neuroregeneration, Nantong University, 226019, Nantong, PR China.
Qimeng WuInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), 400038, Chongqing, PR China.
Chen LiangMultidisciplinary Centre for Advanced Materials, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 201620, Shanghai, PR China.
Jiali HuaDepartment of Hypoxic Biomedicine, Institute of Special Environmental Medicine and Coinnovation Center of Neuroregeneration, Nantong University, 226019, Nantong, PR China.
Lingyi MengDepartment of Hypoxic Biomedicine, Institute of Special Environmental Medicine and Coinnovation Center of Neuroregeneration, Nantong University, 226019, Nantong, PR China.
Paweł NakielskiDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, 02-106, Warsaw, Poland.
Chenyan LuDepartment of Hypoxic Biomedicine, Institute of Special Environmental Medicine and Coinnovation Center of Neuroregeneration, Nantong University, 226019, Nantong, PR China.
Filippo PieriniDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, 02-106, Warsaw, Poland.
Liqun XuBRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, 400715, Chongqing, PR China.
Yunlong YuInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), 400038, Chongqing, PR China.
Qianqian LuoDepartment of Hypoxic Biomedicine, Institute of Special Environmental Medicine and Coinnovation Center of Neuroregeneration, Nantong University, 226019, Nantong, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burn wound management posed substantial therapeutic challenges due to impaired macrophage polarization dynamics. Metabolic dysfunction in macrophages hindered the transition from glycolysis-driven M1 phenotype to oxidative phosphorylation (OXPHOS)-driven M2 phenotype, result of perpetuating inflammatory reaction to restrain wound healing. Despite all kinds of biomaterials were developed for burn wounds, some critical issues still couldnot be solved, such as limited repair efficacy, strong immunogenicity, and high cost

Indexed as

BurnMacrophageMetabolism reprogrammingOXPHOSWound healing

Identifiers

PMID41209694
PMCPMC12593653

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.