Evidence map›Paper›PMID 41209718›Full record

ArticleCurrent research in microbial sciences2025

Reduced fitness and enhanced immunogenicity of

Alina Minias, Lidia Fiedorowicz, Izabela Szulc-Kiełbik, Monika Kozińska, Anna Zabost, Daria Zygała-Pytlos, Katarzyna Struś, Marcin Słomka, Jakub Lach, Dominik Strapagiel and 2 more

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Article in Current research in microbial sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alina MiniasInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Lidia FiedorowiczInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Izabela Szulc-KiełbikInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Monika KozińskaDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Anna ZabostDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Daria Zygała-PytlosInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Katarzyna StruśInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Marcin SłomkaCentre for Digital Biology and Biomedical Science - Biobank Lodz, University of Lodz, Lodz, Poland.
Jakub LachCentre for Digital Biology and Biomedical Science - Biobank Lodz, University of Lodz, Lodz, Poland.
Dominik StrapagielCentre for Digital Biology and Biomedical Science - Biobank Lodz, University of Lodz, Lodz, Poland.
Jarosław DziadekInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.
Ewa Augustynowicz-KopećDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Materials and methods: We compared phenotypic characteristics of 12 genetically unlinked clinical isolates-six each from the Haarlem and Ural families-collected from individual patients in Poland. Growth kinetics, competitive fitness, intracellular replication in macrophages, hypoxia recovery, and host immune responses were evaluated using Results: Ural isolates exhibited significantly slower growth and lower colony-forming units in competitive fitness assays compared to Haarlem isolates. In macrophage infection models, Ural strains showed impaired intracellular replication. Additionally, Ural isolates demonstrated a diminished capacity to resuscitate from hypoxia, indicating possible defects in dormancy recovery. Host immune assays revealed that Ural isolates induced higher levels of IL-12p40, suggesting stronger immune activation. Discussion: Our findings indicate that Ural isolates possess reduced growth fitness and increased immunogenicity compared to Haarlem isolates. These traits may limit their capacity for transmission and persistence in hosts, potentially explaining their restricted geographic distribution. Conclusion: The study highlights the influence of

Indexed as

FitnessGrowth rateHaarlem familyImmunogenicityMycobacterium tuberculosis;Whole genome sequencingUral family

Identifiers

PMID41209718
PMCPMC12590253

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.