ArticleJournal of pain research2025
Causal Association of Alzheimer's Disease with Low Back Pain: A Mendelian Randomization Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Previous observational studies have demonstrated that Low back pain (LBP) often coexists with Alzheimer's Disease (AD), however, the causal relationship remains unclear. The purpose of this study is to explore the causal relationship between AD and LBP through Mendelian randomized analysis. Methods: Instrumental variables (IVs) were derived from the genome-wide association study (GWAS) of AD. Information regarding Instrumental variables (IVs) in LBP was extracted from a GWAS database. MR-Egger, weighted median, inverse variance weighted (IVW)and Weighted mode were used to evaluate the causal effects. Cochran's Q test and MR-Egger intercept were applied to detect the heterogeneity and horizontal pleiotropy, respectively. Outliers were found and remove based on MR-PRESSO analysis to mitigate the effect of horizontal pleiotropy on the results. Deleting each genetic variant applying the leave-one-out analysis can help evaluate the robustness of results. Finally, MR-PRESSO Raw and Outlier-corrected were used to enhance the credibility of the results. Results: IVW assessment provided strong evidence that AD is positively associated with LBP (Odds Ratio (OR)= 1.046, 95% confidence interval(CI) = 1.023-1.070, P=5.8×10 Conclusion: This study provides evidence for a causal relationship between AD and LBP. It emphasizes the necessity of improving pain management for patients with Alzheimer's disease in clinical practice. However, the data were derived from a European population, which may limit the generalizability of the results to other populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.