Evidence map›Paper›PMID 41210299›Full record

ArticleBrain, behavior, & immunity - health2025

Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study.

Jianye Zeng, Xiumei Zhu, Huajie Ba, Shilin Li, Chun Yang, Ping Huang, Anqi Chen, Yingnan Bian, Chengtao Li, Suhua Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianye ZengInstitute of Forensic Science, Fudan University, Shanghai, China.
Xiumei ZhuSchool of Forensic Medicine, China Medical University, Shenyang, China.
Huajie BaDNA Laboratory, Public Security Bureau of Changzhou, Changzhou, Jiangsu Province, China.
Shilin LiInstitute of Forensic Science, Fudan University, Shanghai, China.
Chun YangThe 904th Hospital (Changzhou Branch) of Joint Logistic Support Force of Chinese People's Liberation Army, Changzhou, Jiangsu Province, China.
Ping HuangInstitute of Forensic Science, Fudan University, Shanghai, China.
Anqi ChenInstitute of Forensic Science, Fudan University, Shanghai, China.
Yingnan BianEnlight medical Technologies, Pudong New Area, Shanghai, China.
Chengtao LiInstitute of Forensic Science, Fudan University, Shanghai, China.
Suhua ZhangInstitute of Forensic Science, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Schizophrenia is a severe psychiatric disorder with a complex etiology. Emerging evidence implicates the gut microbiota in its pathogenesis via the microbiota-gut-brain axis, although causal relationships remain unclear. Methods: We used a two-sample Mendelian randomization (MR) approach to investigate potential causal links between gut microbial taxa and schizophrenia. To provide a biological context for these findings, we performed 16S rRNA V3-V4 sequencing of fecal samples from an independent cohort of individuals with schizophrenia (SCZ, n = 21) and matched healthy controls (HC, n = 21). Results: Forward MR analysis revealed a significant causal association between seven microbial taxa and schizophrenia risk. Notably, a higher genetically predicted abundance of Conclusions: By integrating MR with 16S rRNA V3-V4 sequencing, this study provides convergent evidence for a potential causal role of specific gut microbial taxa, particularly

Indexed as

16S rRNA sequencingBifidobacteriumGut-brain axisMendelian randomizationSchizophrenia

Identifiers

PMID41210299
PMCPMC12593211

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.