Evidence map›Paper›PMID 41210729›Full record

ArticleACS omega2025

Vine Tea Combined with a Lidocaine Microneedle Patch for Enhanced Treatment of Psoriasis.

Ziyan Chen, Ying Wang, Ye Kai, Xuanjie Huang, Mingyi Tan, Huayi Wu, Wangqing Chen, Wu Zhu, XiaoWei Liang, Peipei Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ziyan ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID https://orcid.org/0000-0003-4950-1036
Ying WangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Ye KaiDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID https://orcid.org/0009-0002-1838-0171
Xuanjie HuangSchool of Metallurgy and Environment, Central South University, Changsha, Hunan 410083, China.
Mingyi TanDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Huayi WuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Wangqing ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Wu ZhuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
XiaoWei LiangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Peipei WangHunan Qiankun Biotechnology Co., Ltd, Changsha, Hunan 410083, China.
Chao LiuHunan Qiankun Biotechnology Co., Ltd, Changsha, Hunan 410083, China.
Wei ZhengEye Center of Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zeyu ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiang ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Shuang ZhaoDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID https://orcid.org/0000-0001-7081-6177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vine tea, a traditional Chinese herbal tea with well-known medicinal properties, contains various bioactive compounds, with dihydromyricetin (DMY) standing out as particularly notable. However, the therapeutic potential of DMY is hindered by its low solubility and limited ability to penetrate cell membranes. In this study, we present a novel approach utilizing a microneedle (MN) patch loaded with DMY in combination with lidocaine (LD), referred to as the DMY-LD MN patch, to effectively target thickened skin lesions in the treatment of psoriasis. The DMY-LD MN patch demonstrated the ability to penetrate the thickened epidermal layers associated with psoriasis, enabling sustained release of DMY and LD at the site of the skin lesion. In a murine model of psoriasis, both DMY and LD showed therapeutic efficacy when administered individually. Notably, the combined DMY and LD treatment regimen exhibited superior therapeutic outcomes. The DMY-LD MN patch offers a promising treatment strategy for psoriasis due to its durability, efficacy, cost-effectiveness, and safety.

Identifiers

PMID41210729
PMCPMC12593055

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.