Evidence map›Paper›PMID 41210766›Full record

ArticleACS omega2025

Chemodiversity of Cyanobacteria from Brazil Investigated by Metabolomics and Bioassays.

Francisco H S da Silva, Leonardo S de Jesus, Michael J J Recchia, Kleyton J G de Morais, Camila M C Gonçalves, Sandra R C Soares, Helori V Domingos, Hannah Cavanagh, Frederico J Gueiros-Filho, José A L Lindoso and 4 more

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francisco H S da SilvaFaculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo 05508-000, São Paulo, Brazil.
Leonardo S de JesusFaculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo 05508-000, São Paulo, Brazil.
Michael J J RecchiaDepartment of Chemistry, Simon Fraser University, Burnaby V5A 1S6, British Columbia, Canada.
Kleyton J G de MoraisInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13560-970, São Paulo, Brazil.
Camila M C GonçalvesLaboratório de Prozoologia, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, São Paulo, Brazil.
Sandra R C SoaresLaboratório de Prozoologia, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, São Paulo, Brazil.
Helori V DomingosDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, São Paulo, Brazil.
Hannah CavanaghDepartment of Chemistry, Simon Fraser University, Burnaby V5A 1S6, British Columbia, Canada.
Frederico J Gueiros-FilhoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13560-970, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5425-2439
José A L LindosoLaboratório de Prozoologia, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, São Paulo, Brazil.
Leticia V Costa-LotufoDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1861-5153
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby V5A 1S6, British Columbia, Canada.ORCID https://orcid.org/0000-0003-1818-4971
Roberto G S BerlinckInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13560-970, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0118-2523
Camila M CrnkovicFaculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo 05508-000, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6581-9031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Investigations on cyanobacterial secondary metabolites in Brazil have been scarce, despite the country's significant biodiversity. Herein, we report the results of a screening of cyanobacterial cultures using both bioassays and untargeted metabolomics. Nineteen cyanobacterial strains collected at various locations in Brazil were cultured. Cultures were extracted and prefractionated. Fractions were evaluated for antibacterial, cytotoxic, and antileishmanial activities. The same fractions were analyzed by UHPLC-HRMS-MS/MS. Results from bioassays and LC-MS were integrated using metabolomics tools such as NP Analyst and GNPS Molecular Networking, allowing for feature prioritization. Cyanobacteria belonging to genera

Identifiers

PMID41210766
PMCPMC12593024

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.