SynthesisFrontiers in medicine2025
Vitamin D levels in early and middle pregnancy and preeclampsia: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background and aims: Previous studies have indicated a potential association between low vitamin D levels in early pregnancy and an increased risk of hypertensive disorders, including preeclampsia. Given the substantial maternal and fetal morbidity associated with preeclampsia, identifying preventive strategies is crucial. This meta-analysis aimed to evaluate the relationship between vitamin D status in early and middle pregnancy and the development of preeclampsia. Methods: A comprehensive literature search of PubMed, Scopus, Web of Science, and Cochrane Library databases was conducted up to June 23, 2023, to identify relevant observational studies. Included studies were assessed for methodological quality, and data on maternal vitamin D concentration and the risk of preeclampsia were extracted. Results: Twenty-nine observational studies with 74,061 participants were included. Women with preeclampsia had significantly lower vitamin D levels than those without (SMD -0.28, 95% CI -0.39 to -0.17, Conclusion: The findings of this meta-analysis suggest a potential association between low maternal vitamin D levels and an increased risk of preeclampsia, particularly when measured prior to the late pregnancy. However, the precise timing of this association requires further investigation. To definitively establish the role of vitamin D supplementation in preventing preeclampsia, well-designed randomized controlled trials are needed to determine optimal dosage and timing of intervention, as well as to assess cost-effectiveness. Systematic review registration: Registered in OSF: https://osf.io/qwh6a (Unique ID: qwh6a).
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