ArticleiScience2025
Proximity interactome mapping furthers a role for spinophilin in protein homeostasis.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Proteomic Characterization of Striatal Neurabin Interactome and Its Sex Specific Impact on Motor Behavior.ACS chemical neuroscience · 2026Article
- Striatal spinophilin enhances dopamine D2 receptor (D2R) interaction with cytosolic proteins to mediate persistent D2R agonist-induced locomotor suppression.The Journal of pharmacology and experimental therapeutics · 2026Article
- Proteomic Characterization of Striatal Neurabin Interactome and its Sex Specific Impact on Motor Behavior.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Spinophilin is a dendritic spine-enriched scaffolding and protein phosphatase 1-targeting protein. To detail spinophilin-interacting proteins, we created an UltraID and ALFA-tagged spinophilin-encoding construct that permits proximity labeling and orthogonal nanobody pull-down (ID-oPD) of spinophilin-associated protein complexes in heterologous cells. Using this ID-oPD approach, we identified 614 UltraID-specific and 312 UltraID-specific and spinophilin-selective spinophilin-interacting proteins in HEK293 cells and validated a subset of these using orthogonal approaches. Many of these proteins are involved in mRNA processing and translation. In the brain, we determined that spinophilin mRNA is highly neuropil localized and that spinophilin may normally function to limit its own expression but promote the expression of other postsynaptic density (PSD)-associated proteins. Overall, our use of an ID-oPD approach uncovers a putative role for spinophilin in mRNA translation and PSD protein expression.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.