Evidence map›Paper›PMID 41211332›Full record

ArticleFrontiers in neuroscience2025

Lanboling Guo, Jessica R Gaunt, Calvin Chee Hoe Cheah, Albert I Chen, Stephanie Claudine, Gavin S Dawe, Eyleen Lay Keow Goh, Sok-Hong Kho, Pawan Kumar, Grace G Y Lim and 11 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lanboling Guo *Neuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Jessica R Gaunt *Neuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Calvin Chee Hoe CheahNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Albert I ChenSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Stephanie ClaudineNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Gavin S DaweDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Eyleen Lay Keow GohNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Sok-Hong KhoNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Pawan KumarDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Grace G Y LimNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Kah Leong LimNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Yun-An LimDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Takaomi C SaidoRIKEN Center for Brain Science, Saitama, Japan.
Takashi SaitoDepartment of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroki SasaguriDementia Pathophysiology Collaboration Unit, RIKEN Center for Brain Science, Wako, Japan.
Judy C G SngDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yee Jie YeapNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Alaric K K YipNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Norliyana ZainolabidinNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Toh Hean Ch'ngNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
George J AugustineNeuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: We generated and characterized double-mutant knock-in mice incorporating familial Results: In the brains of 3-month-old double-mutant mice there were significant alterations in vascular remodeling genes, vascular structure and blood-brain barrier permeability. These changes were not observed in either Conclusion: These findings indicate that early vascular changes, driven by the interaction of

Indexed as

APOE4APPcerebral vasculaturedementiatranscriptomics

Identifiers

PMID41211332
PMCPMC12592981

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.