Evidence map›Paper›PMID 41211539›Full record

ArticleBone reports2025

Nanostructural changes in bone quality in a mouse model of chronic kidney disease and treatment with calcitonin.

E Montagnino, W Bush, J Bustamante, W Bandara, P Jalaie, M R Allen, J M Wallace, T Siegmund, R K Surowiec, J A Howarter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

E MontagninoSchool of Materials Engineering, Purdue University, West Lafayette, USA.
W BushSchool of Mechanical Engineering, Purdue University, West Lafayette, USA.
J BustamanteWeldon School of Biomedical Engineering, Purdue University, West Lafayette, USA.
W BandaraWeldon School of Biomedical Engineering, Purdue University, West Lafayette, USA.
P JalaieWeldon School of Biomedical Engineering, Purdue University, West Lafayette, USA.
M R AllenIndiana University School of Medicine, Indianapolis, USA.
J M WallaceWeldon School of Biomedical Engineering, Purdue University, West Lafayette, USA.
T SiegmundSchool of Mechanical Engineering, Purdue University, West Lafayette, USA.
R K SurowiecWeldon School of Biomedical Engineering, Purdue University, West Lafayette, USA.
J A HowarterSchool of Materials Engineering, Purdue University, West Lafayette, USA.

Funding

BLRD VA I01 BX003025BLRD VA IK6 BX006479
6 · The paper itself

Abstract

Mineral imbalances in the body from chronic kidney disease can impact bone turnover and cause cortical bone loss. Synthetic salmon calcitonin is an FDA-approved treatment for bone fragility observed in diseases such as osteoporosis, and clinical trials have demonstrated a reduction in fractures compared to untreated individuals. This study documents the effects of calcitonin on cortical bone using an in vivo mouse model of chronic kidney disease. Serum BUN and PTH are reported. Calcitonin was found to impact at a dose of 50/IU/kg/day five times a week for five weeks. MicroCT was used to evaluate bone quantity measures, such as cortical porosity, thickness, bone area, and long bone structural geometric parameters. It was found that porosity, thickness, and bone geometry are affected by disease, but not by treatment at the specified regime. Small and wide-angle x-ray scattering (SAXS and WAXS) was used to obtain the nanostructure of the mineral-collagen-water composite, including mineral dimensions,

Indexed as

BoneBone massBone nanostructureBone structureCalcitoninChronic kidney diseaseMicro CTMouse modelSAXSThermogravimetric analysisWAXSX-ray scattering

Identifiers

PMID41211539
PMCPMC12590260

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.