Evidence map›Paper›PMID 41211723›Full record

ArticleJournal of medicinal chemistry2025

FDA Drug Repurposing Uncovers Modulators of Dopamine D

Daniel Muñoz-Reyes, Lorena Aguado, Sandra Arroyo-Urea, Carlos Requena, Sara Pérez-Suárez, Sonia Sánchez-Yepes, Josep Argerich, Celia Miró-Rodríguez, Eugenia Ulzurrun, Eulalia Rodríguez-Martín and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel Muñoz-ReyesDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry "Blas Cabrera", CSIC, Serrano 119, 28006 Madrid, Spain.ORCID 0000-0001-8464-1996
Lorena AguadoDepartment of Neurobiology, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Sandra Arroyo-UreaInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, 50018 Zaragoza, Spain.
Carlos RequenaCentro de Investigaciones Biológicas Margarita Salas - CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain.
Sara Pérez-SuárezDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry "Blas Cabrera", CSIC, Serrano 119, 28006 Madrid, Spain.
Sonia Sánchez-YepesDepartment of Neurobiology, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Josep ArgerichInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, 50018 Zaragoza, Spain.
Celia Miró-RodríguezDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry "Blas Cabrera", CSIC, Serrano 119, 28006 Madrid, Spain.
Eugenia UlzurrunCentro de Investigaciones Biológicas Margarita Salas - CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain.
Eulalia Rodríguez-MartínDepartment of Neurobiology, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Javier García-NafríaInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Laboratorio de Microscopías Avanzadas (LMA), University of Zaragoza, 50018 Zaragoza, Spain.
Nuria E CampilloCentro de Investigaciones Biológicas Margarita Salas - CSIC, C/Ramiro de Maeztu 9, 28040 Madrid, Spain.ORCID 0000-0002-9948-2665
Alicia MansillaDepartment of Neurobiology, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
María José Sánchez-BarrenaDepartment of Crystallography and Structural Biology, Institute of Physical-Chemistry "Blas Cabrera", CSIC, Serrano 119, 28006 Madrid, Spain.ORCID 0000-0002-5986-1804

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine D

Indexed as

Drug RepositioningNeuronal Calcium-Sensor ProteinsReceptors, Dopamine D2HEK293 CellsHumansNeuropeptidesProtein BindingUnited States Food and Drug Administrationfrequenin calcium sensor proteinsNeuronal Calcium-Sensor ProteinsNeuropeptidesReceptors, Dopamine D2

Identifiers

PMID41211723
PMCPMC12670427

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.