Evidence map›Paper›PMID 41212267›Full record

ArticleSurgery today2026

Prognostic factors for 5 year relapse-free survivors following curative resection for stage II/III colorectal cancer.

Takeru Itoi, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Junichi Takamizawa, Norihiro Yuasa

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takeru ItoiDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Hideo MiyakeDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Hidemasa NagaiDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Yuichiro YoshiokaDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Junichi TakamizawaDepartment of Laboratory Medicine, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.
Norihiro YuasaDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan. nyuasa0257@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWith an increasing number of individuals surviving colorectal cancer (CRC), it is important to identify prognostic factors to determine follow-up strategies beyond 5 years. This study investigated the clinical factors associated with the overall survival (OS), disease-specific survival (DSS), and non-disease-specific survival (NDSS) in survivors who remained relapse-free for 5 years following curative resection for stage II/III CRC.

methodsAmong 1536 patients who underwent curative resection for stage II/III CRC between 2003 and 2018, 881 who remained relapse-free for 5 years were included. The OS, DSS, and NDSS beyond 5 years were analyzed using univariate and multivariate methods.

resultsThe mean age was 77.5 years, and 54.6% were male. During a median follow-up of 34 months beyond 5 years, 87 individuals died (5 disease-specific and 73 non-disease-specific). The 5 year OS, DSS, and NDSS rates were 92%, 99%, and 92%, respectively. Multivariate analysis identified age ≥ 80 years, serum carcinoembryonic antigen ≥ 5.0 ng/mL, anemia, mean corpuscular volume ≥ 100 fL, and red cell distribution width (RDW) ≥ 14.9% as independent predictors of a poor OS.

conclusionsFive clinical factors-age ≥ 80 years, elevated CEA level, anemia, macrocytosis, and a high RDW-were identified as independent prognostic indicators among 5 year relapse-free survivors after stage II/III CRC resection. These findings highlight the importance of individualized long-term follow-up strategies, even beyond 5 years after surgery.

Indexed as

Cancer SurvivorsColectomyColorectal NeoplasmsNeoplasm Recurrence, LocalAgedAged, 80 and overAge FactorsAnemiaCarcinoembryonic AntigenDisease-Free SurvivalErythrocyte IndicesFemaleFollow-Up StudiesHumansMaleMultivariate AnalysisCarcinoembryonic AntigenColorectal cancerMean corpuscular volumeRed cell distribution widthRelapse-free survivorSurvival

Identifiers

PMID41212267

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.