Evidence map›Paper›PMID 41212365›Full record

ReviewCurrent atherosclerosis reports2025

Beyond LDL Cholesterol Reduction: Pleiotropic Profiling of Statins.

Tanesh Ayyalu, Tia Bimal, Maya S Safarova, Zohaib M Bagha, Allen J Taylor, Peter P Toth

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tanesh AyyaluDepartment of Cardiology, MedStar Heart and Vascular Institute, Washington, DC, USA.
Tia BimalDepartment of Cardiology, Lenox Hill, Manhattan, NY, USA.
Maya S SafarovaDivision of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Zohaib M BaghaDepartment of Medicine, Zucker School of Medicine at Hofstra/Northwell at Northern Westchester Hospital, Mount Kisco, NY, USA.
Allen J TaylorDepartment of Cardiology, MedStar Heart and Vascular Institute, Washington, DC, USA.
Peter P TothDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Peter.Toth@cghmc.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewStatins, primarily known for their cholesterol-lowering capabilities, exert a wide range of effects on metabolic biomarkers, known as pleiotropic effects, that extend beyond atherosclerosis. This review highlights the molecular mechanisms and systemic impact of statins, encompassing their anti-inflammatory, anti-oxidative, endothelial-protective, and antithrombotic properties. RECENT

findingsStatins have been shown to improve outcomes in cardiovascular conditions such as arrhythmias, non-ischemic cardiomyopathy and heart failure, as well as reduce thrombotic events such as venous thromboembolism. Beyond the cardiovascular system, statins demonstrate potential for benefit in metabolic regulation, renal protection, bone health, gastrointestinal inflammation, and neurological conditions. However, controversy remains regarding the extent to which these benefits are mediated by lipid-independent mechanisms. This comprehensive overview underscores the expanding therapeutic role of statins across diverse clinical contexts and identifies areas for future research to optimize their use in special patient populations.

Indexed as

Cardiovascular DiseasesCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsAnimalsAnti-Inflammatory AgentsAntioxidantsBiomarkersHumansInflammationAnti-Inflammatory AgentsAntioxidantsBiomarkersCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationPleiotropic effectsPreventionStatins

Identifiers

PMID41212365

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.