ArticleJournal of endocrinological investigation2026
Metabolic complications in a large cohort of Portuguese women with hirsutism-related disorders.
Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundHirsutism in women, defined as excessive terminal hair growth in androgen-dependent areas, is associated with hyperandrogenic disorders such as Polycystic Ovary Syndrome (PCOS) and Non-classic Congenital Adrenal Hyperplasia (NCAH), and non-hyperandrogenic disorders like Idiopathic Hirsutism (IH). These conditions have been linked to metabolic complications, including insulin resistance, diabetes mellitus, and cardiovascular risks. Nevertheless, their specific metabolic profiles continue to require further investigation. PURPOSE: This study aims to evaluate the prevalence and severity of metabolic complications, including insulin resistance and lipid abnormalities, in women with PCOS, NCAH, Idiopathic Hyperandrogenemia (IHA), and IH compared to healthy controls.
methodsA cross-sectional study was conducted on 600 women attending endocrinology consultations at a tertiary hospital from 2010 to 2022. Participants were classified into diagnostic groups based on established criteria, and metabolic parameters were assessed. Statistical analyses included non-parametric tests and ROC curve analyses to identify significant differences and discriminatory markers.
resultsPatients with PCOS, NCAH, and IHA exhibited higher fasting insulin levels compared to controls. PCOS patients also demonstrated increased HOMA-IR, decreased QUICKI index, and lower HDL levels relative to controls. BMI differences were significant only for PCOS compared to controls. ROC analyses revealed HOMA-IR and fasting insulin levels as potential discriminators between PCOS and controls.
conclusionsMetabolic complications such as insulin resistance are prevalent in women with hyperandrogenism, highlighting the need for targeted metabolic screening in hirsutism-related disorders. Our study highlights the necessity to comprehensively demonstrate the metabolic alterations in these conditions and the ways that shall be employed to treat them. Further research is warranted to explore underlying mechanisms and intervention strategies.
Indexed as
Identifiers
41212409What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.