Evidence map›Paper›PMID 41212457›Full record

ReviewMedical oncology (Northwood, London, England)2025

A review on the role of IL-6 in the onset and progression of nasopharyngeal carcinoma.

Yangyang Tao, Lan He, Binya Wang, Mei Jiang, Le Tang, Jingjing Luo, Ting Lin, Yingchun He

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yangyang TaoHunan University of Chinese Medicine, Changsha, P.R. China.
Lan HeThe First Hospital of Hunan University of Chinese Medicine, Changsha, P.R. China.
Binya WangHunan University of Chinese Medicine, Changsha, P.R. China.
Mei JiangHunan University of Chinese Medicine, Changsha, P.R. China.
Le TangHunan University of Chinese Medicine, Changsha, P.R. China.
Jingjing LuoHunan University of Chinese Medicine, Changsha, P.R. China.
Ting LinHunan University of Chinese Medicine, Changsha, P.R. China. 004586@hnucm.edu.cn.
Yingchun HeHunan University of Chinese Medicine, Changsha, P.R. China. heyingchun@hnucm.edu.cn.

Funding

Chinese Academy of Engineering Academician Liang Liu's Workstation of Hunan University of Chinese Medicine 22YS001First-class Discipline Construction Project of Hunan University of Chinese Medicine 22JBZ011Hunan Provincial Health High-Level Talent Scientific Research Project R2023111the National Natural Science Foundation of China 82305329the National Natural Science Foundation of China 82405496the Natural Science Foundation of Changsha City kq2208206the Natural Science Foundation of Hunan Province 2023JJ30449the Natural Science Foundation of Hunan Province 2023JJ40500the Project of Hunan Provincial Department of Education 23A0298the Project of Hunan Provincial Health Commission 202207015049the Project of Hunan University of Chinese Medicine S202310541100
6 · The paper itself

Abstract

Nasopharyngeal carcinoma is a type of malignant tumour occurring in the nasopharyngeal mucosal epithelium. This carcinoma often has no obvious symptoms in the early stages and is frequently diagnosed at mid-to-advanced stages. Interleukin-6 (IL-6) is a multifunctional cytokine that can participate in the regulation of the immune system, haematopoiesis, induction of acute phase protein secretion, and cell proliferation and differentiation of. IL-6 is a core molecule in tumour inflammation and carcinoma metastasis that promotes various tumours. This article discusses the promoting effects of IL-6 in the occurrence and development of nasopharyngeal carcinoma from the perspectives of release of pro-inflammatory factors, regulation of the tumour microenvironment, enhanced migration and invasion abilities of tumour cells and distant metastasis, and improved tumour immune evasion functions. In addition, important implications of IL-6 for the diagnosis, treatment, and prognosis of nasopharyngeal carcinoma are discussed.

Indexed as

Interleukin-6Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsAnimalsCarcinomaDisease ProgressionHumansPrognosisTumor MicroenvironmentIL6 protein, humanInterleukin-6IL-6Nasopharyngeal carcinomaProgressionTreatment

Identifiers

PMID41212457

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.