Evidence map›Paper›PMID 41212462›Full record

ArticleMolecular biomedicine2025

E3 ligase CHIP restoration facilitates the effect of α

Wan Lin, Hang Li, Hin Fong, Xingyu Su, Junhao Wen, Xianyun Shao, Ziqing Yan, Yiyang Wang

Abstract read
In one paragraph

Article in Molecular biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wan Lin *Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Hang Li *Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Hin Fong *Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Xingyu SuDepartment of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Junhao WenDepartment of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Xianyun ShaoDepartment of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Ziqing YanDepartment of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
Yiyang WangDepartment of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China. wangyiyang@jnu.edu.cn.ORCID 0000-0001-9562-0621

Funding

National Natural Science Foundation of China 82072138
6 · The paper itself

Abstract

Myocardial fibrosis is a serious complication in sepsis and leads to cardiac dysfunction. The carboxy terminus of Hsc70-interacting protein (CHIP), a U-box E3 ligase, defends against sepsis-caused cardiac injury. Here, we explored a novel therapeutic effect of α

Indexed as

Adrenergic alpha-1 Receptor AntagonistsMyocardiumReceptors, Adrenergic, alpha-1Smad2 ProteinSmad3 ProteinUbiquitin-Protein LigasesAnimalsCell DifferentiationDown-RegulationFibroblastsFibrosisLipopolysaccharidesMaleMiceMice, Inbred C57BLNorepinephrineAdrenergic alpha-1 Receptor AntagonistsLipopolysaccharidesNorepinephrinePrazosinReceptors, Adrenergic, alpha-1Smad2 ProteinSmad2 protein, mouseSmad3 ProteinUbiquitin-Protein LigasesCardiac fibrosisCHIPFibroblastLipopolysaccharideNorepinephrineα1-AR

Identifiers

PMID41212462
PMCPMC12602763

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.