ArticleAmerican journal of physiology. Endocrinology and metabolism2025
Role of complexin 2 in the regulation of hormone secretion from the islet of Langerhans.
Xue Wen Ng, Chen Kong, Michael R DiGruccio, Jeongmin Lee, David W Piston
Abstract read
In one paragraphArticle in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
5 authors.
Xue Wen NgDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States.ORCID 0000-0001-6252-8052 Chen KongDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States.
Michael R DiGruccioDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States.
Jeongmin LeeDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States.ORCID 0000-0003-2554-4285 David W PistonDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States.ORCID 0000-0002-1200-3116 Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MRegulation of Glucagon Secretion from Pancreatic IsletsR01DK123301 · NIDDK · WASHINGTON UNIVERSITY · PI PISTON, DAVID W · 2020 to 2024
$2.0MMulti-dimensional Dynamics of Pancreatic Islet Cells Measured by Image Mapping diSPIMR01DK115972 · NIDDK · WASHINGTON UNIVERSITY · PI PISTON, DAVID W · 2018 to 2021
$1.7MHHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) P30DK020579HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK115972HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK123301Leona M. and Harry B. Helmsley Charitable Trust (Helmsley) G-1912-03558Leona M. and Harry B. Helmsley Charitable Trust (Helmsley) G-2001-04215Leona M. and Harry B. Helmsley Charitable Trust (Helmsley) G-2305-06050NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK115972NIDDK NIH HHS R01 DK123301
6 · The paper itselfAbstract
Regulated secretion of insulin from β-cells, glucagon from α-cells, and somatostatin from δ-cells is necessary for the maintenance of glucose homeostasis. The release of these hormones from pancreatic islets requires the assembly and disassembly of the SNARE protein complex to control vesicle fusion. Complexin 2 (Cplx 2) is a small soluble synaptic protein that participates in the priming and release of vesicles. It plays a dual role as a molecular switch that clamps and prevents fusion pore opening, which subsequently undergoes a conformational change upon Ca
Indexed as
Adaptor Proteins, Vesicular TransportGlucagonInsulinInsulin SecretionIslets of LangerhansNerve Tissue ProteinsSomatostatinAnimalsExocytosisGlucagon-Secreting CellsGlucoseInsulin-Secreting CellsMaleMiceMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Vesicular Transportcomplexin IIGlucagonGlucoseInsulinNerve Tissue ProteinsSomatostatincomplexin 2hormone secretionpancreatic isletparacrine interactionvesicle fusion
Identifiers
PMID41212554
PMCPMC12990977
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