SynthesisPLoS neglected tropical diseases2025
Anthropometric and neurocognitive consequences of Campylobacter, enterotoxigenic Escherichia coli, and norovirus: A systematic review.
Synthesis in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesSynthesizing the evidence of the longer-term consequences of enteric pathogens, such as stunted growth and suboptimal neurodevelopment, is a key step to articulating the value of, and generating demand for, vaccines.
methodsWe conducted a systematic review of published literature documenting associations of three leading causes of diarrhea (enterotoxigenic Escherichia coli [ETEC], norovirus, and Campylobacter species [sp.]) with prospective anthropometric and neurocognitive outcomes in children under five years (PROSPERO CRD42024600676).
resultsThirty publications were included, including several reporting on data from the same underlying cohort; 16 publications included outcomes associated with Campylobacter, 12 ETEC, and 7 norovirus. There was large variation in how studies reported outcomes, exposure groups, and timeframes of association. There was modest evidence of linear growth detriments associated with all three pathogens, modest evidence of Campylobacter limiting weight gain, and no evidence of detrimental impacts of these pathogens on wasting or neurodevelopment, albeit these two outcomes were rarely reported.
conclusionDifferences in outcome definitions, comparison groups, and timeframes prohibited meta-analysis and emphasize the need for more standardization of reporting anthropometric and neurocognitive outcomes following enteric pathogen infection. Randomized controlled trials of efficacious pathogen-specific interventions may help to address challenges with confounding and reverse causality in observational studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.